ACOT11


Summary: This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
acyl-CoA thioesterase 11MIM:606803Ensembl:ENSG00000162390HGNC:HGNC:18156PA383031p32.3

GO terms in ACOT11


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000062fatty-acyl-CoA binding
MFIEAGO:0008289lipid binding
MFIBAGO:0016290palmitoyl-CoA hydrolase activity
MFIBAGO:0036042long-chain fatty acyl-CoA binding
MFIBAGO:0047617acyl-CoA hydrolase activity
MFTASGO:0047617acyl-CoA hydrolase activity
MFIEAGO:0052689carboxylic ester hydrolase activity
BPIBAGO:0006631fatty acid metabolic process
BPNASGO:0006631fatty acid metabolic process
BPIBAGO:0006637acyl-CoA metabolic process
BPTASGO:0006637acyl-CoA metabolic process
BPISSGO:0009266response to temperature stimulus
BPIBAGO:0009409response to cold
BPISSGO:0009409response to cold
BPNASGO:0035556intracellular signal transduction
BPIBAGO:1900535palmitic acid biosynthetic process
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: ACOT11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ACOT11


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-77289Mitochondrial Fatty Acid Beta-Oxidation
reactomeR-HSA-8978868Fatty acid metabolism

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACOT11

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