ACOX2
Summary: The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe cognitive disability, and death in children. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| acyl-CoA oxidase 2 | MIM:601641 | Ensembl:ENSG00000168306 | HGNC:HGNC:120 | PA24444 | 3p14.3 |
GO terms in ACOX2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003995 | acyl-CoA dehydrogenase activity |
| MF | IBA | GO:0003997 | acyl-CoA oxidase activity |
| MF | TAS | GO:0003997 | acyl-CoA oxidase activity |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IBA | GO:0005504 | fatty acid binding |
| MF | TAS | GO:0016402 | pristanoyl-CoA oxidase activity |
| MF | IBA | GO:0033791 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity |
| MF | IDA | GO:0033791 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity |
| MF | ISS | GO:0033791 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0050660 | flavin adenine dinucleotide binding |
| MF | ISS | GO:0050660 | flavin adenine dinucleotide binding |
| MF | IEA | GO:0071949 | FAD binding |
| CC | IBA | GO:0005777 | peroxisome |
| CC | IDA | GO:0005777 | peroxisome |
| CC | IMP | GO:0005777 | peroxisome |
| CC | ISS | GO:0005777 | peroxisome |
| CC | TAS | GO:0005782 | peroxisomal matrix |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | TAS | GO:0006625 | protein targeting to peroxisome |
| BP | TAS | GO:0006699 | bile acid biosynthetic process |
| BP | IDA | GO:0010942 | positive regulation of cell death |
| BP | IBA | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| BP | IBA | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase |
| BP | IDA | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase |
| BP | IMP | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase |
| BP | TAS | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase |
| BP | IBA | GO:0055088 | lipid homeostasis |
| BP | IDA | GO:1902884 | positive regulation of response to oxidative stress |
Gene expression in normal tissue: ACOX2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ACOX2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2435 | Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis |
| wikipathways | WP3942 | PPAR signaling pathway |
| smpdb | SMP00035 | Bile Acid Biosynthesis |
| smpdb | SMP00314 | Congenital Bile Acid Synthesis Defect Type II |
| smpdb | SMP00315 | Cerebrotendinous Xanthomatosis (CTX) |
| smpdb | SMP00316 | Zellweger Syndrome |
| smpdb | SMP00317 | Familial Hypercholanemia (FHCA) |
| smpdb | SMP00318 | Congenital Bile Acid Synthesis Defect Type III |
| smpdb | SMP00720 | 27-Hydroxylase Deficiency |
| kegg | hsa00120 | Primary bile acid biosynthesis - Homo sapiens (human) |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04146 | Peroxisome - Homo sapiens (human) |
| humancyc | PWY-6061 | bile acid biosynthesis, neutral pathway |
| humancyc | PWY66-391 | fatty acid β-oxidation (peroxisome) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-192105 | Synthesis of bile acids and bile salts |
| reactome | R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| reactome | R-HSA-194068 | Bile acid and bile salt metabolism |
| reactome | R-HSA-389887 | Beta-oxidation of pristanoyl-CoA |
| reactome | R-HSA-390918 | Peroxisomal lipid metabolism |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8957322 | Metabolism of steroids |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| reactome | R-HSA-9033241 | Peroxisomal protein import |
| reactome | R-HSA-9033241 | Peroxisomal protein import |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ACOX2
CLASSFICATION
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