Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016].

ADAM metallopeptidase with thrombospondin type 1 motif 8MIM:605175Ensembl:ENSG00000134917HGNC:HGNC:224PA2455211q24.3

GO terms in ADAMTS8

Term TypeEvidence TypeGO Term IDGO Des.
CCISSGO:0062023collagen-containing extracellular matrix
BPTASGO:0008285negative regulation of cell proliferation
BPIEAGO:0035435phosphate ion transmembrane transport
MFIEAGO:0004222metalloendopeptidase activity
MFTASGO:0005178integrin binding
MFIEAGO:0008201heparin binding
MFTASGO:0008237metallopeptidase activity
MFIEAGO:0008270zinc ion binding
MFTASGO:0009673low-affinity phosphate transmembrane transporter activity

Gene expression in normal tissue: ADAMTS8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADAMTS8

DatabasePathway IDPathway Des.
reactomeR-HSA-1474228Degradation of the extracellular matrix
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-3781865Diseases of glycosylation
reactomeR-HSA-3906995Diseases associated with O-glycosylation of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)
reactomeR-HSA-5173105O-linked glycosylation
reactomeR-HSA-5173214O-glycosylation of TSR domain-containing proteins
reactomeR-HSA-597592Post-translational protein modification

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAMTS8