ADGRE2
Summary: This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| adhesion G protein-coupled receptor E2 | MIM:606100 | Ensembl:ENSG00000127507 | HGNC:HGNC:3337 | PA27774 | 19p13.12 |
GO terms in ADGRE2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0001965 | G-protein alpha-subunit binding |
| MF | IBA | GO:0004930 | G-protein coupled receptor activity |
| MF | IEA | GO:0004930 | G-protein coupled receptor activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IMP | GO:0035374 | chondroitin sulfate binding |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0031256 | leading edge membrane |
| CC | IEA | GO:0032587 | ruffle membrane |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IMP | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IMP | GO:0016477 | cell migration |
| BP | IMP | GO:0043304 | regulation of mast cell degranulation |
| BP | IMP | GO:0071621 | granulocyte chemotaxis |
Gene expression in normal tissue: ADGRE2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADGRE2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP117 | GPCRs, Other |
| wikipathways | WP334 | GPCRs, Class B Secretin-like |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373080 | Class B/2 (Secretin family receptors) |
| reactome | R-HSA-500792 | GPCR ligand binding |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADGRE2
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