Summary: This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].

adhesion G protein-coupled receptor E2MIM:606100Ensembl:ENSG00000127507HGNC:HGNC:3337PA2777419p13.12

GO terms in ADGRE2

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0001965G-protein alpha-subunit binding
MFIBAGO:0004930G-protein coupled receptor activity
MFIEAGO:0004930G-protein coupled receptor activity
MFIEAGO:0005509calcium ion binding
MFIMPGO:0035374chondroitin sulfate binding
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIEAGO:0016021integral component of membrane
CCIDAGO:0031256leading edge membrane
CCIEAGO:0032587ruffle membrane
BPIEAGO:0006954inflammatory response
BPIMPGO:0007155cell adhesion
BPIEAGO:0007166cell surface receptor signaling pathway
BPIEAGO:0007186G-protein coupled receptor signaling pathway
BPIMPGO:0016477cell migration
BPIMPGO:0043304regulation of mast cell degranulation
BPIMPGO:0071621granulocyte chemotaxis

Gene expression in normal tissue: ADGRE2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADGRE2

DatabasePathway IDPathway Des.
wikipathwaysWP117GPCRs, Other
wikipathwaysWP334GPCRs, Class B Secretin-like
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373080Class B/2 (Secretin family receptors)
reactomeR-HSA-500792GPCR ligand binding

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADGRE2