Summary: This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011].

adhesion G protein-coupled receptor E5MIM:601211Ensembl:ENSG00000123146HGNC:HGNC:1711PA2624819p13.12

GO terms in ADGRE5

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0001965G-protein alpha-subunit binding
MFTASGO:0004888transmembrane signaling receptor activity
MFIBAGO:0004930G-protein coupled receptor activity
MFIEAGO:0004930G-protein coupled receptor activity
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCHDAGO:0005925focal adhesion
CCTASGO:0030667secretory granule membrane
CCHDAGO:0070062extracellular exosome
BPTASGO:0006954inflammatory response
BPTASGO:0006955immune response
BPIEAGO:0007155cell adhesion
BPIEAGO:0007166cell surface receptor signaling pathway
BPIEAGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007267cell-cell signaling
BPTASGO:0043312neutrophil degranulation

Gene expression in normal tissue: ADGRE5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADGRE5

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373080Class B/2 (Secretin family receptors)
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-6798695Neutrophil degranulation
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP334GPCRs, Class B Secretin-like

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADGRE5