AFF3


Summary: This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
AF4/FMR2 family member 3MIM:601464Ensembl:ENSG00000144218HGNC:HGNC:6473PA302642q11.2

GO terms in AFF3


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIMPGO:0034612response to tumor necrosis factor
BPIMPGO:0035116embryonic hindlimb morphogenesis
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCIBAGO:0008023transcription elongation factor complex
CCIDAGO:0016604nuclear body
CCIBAGO:0032783ELL-EAF complex
MFIBAGO:0003690double-stranded DNA binding
MFIDAGO:0003690double-stranded DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity

Gene expression in normal tissue: AFF3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AFF3


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832401
iGMDRD193Fqi11
iGMDRD945ML2143
iGMDRD126Tipifarnib7
iGMDRD433Lexibulin3
iGMDRD1008SR-II-138A3
iGMDRD345Compound 10b [PMID: 11504634]4
iGMDRD405PIK-752
iGMDRD188Piperlongumine2
iGMDRD414MST-3123
iGMDRD100Zebularine1
iGMDRD300Tozasertib3
iGMDRD60Quinoclamine3
iGMDRD137Indisulam3
iGMDRD202Curcumin1
iGMDRD105Triptolide2
iGMDRD289Parthenolide3
iGMDRD77Itraconazole4
iGMDRD187BRD98764

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AFF3

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