AGPAT2


Summary: This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
1-acylglycerol-3-phosphate O-acyltransferase 2MIM:603100Ensembl:ENSG00000169692HGNC:HGNC:325PA246229q34.3

GO terms in AGPAT2


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0001819positive regulation of cytokine production
BPICGO:0001961positive regulation of cytokine-mediated signaling pathway
BPNASGO:0006644phospholipid metabolic process
BPIBAGO:0006654phosphatidic acid biosynthetic process
BPIGIGO:0006654phosphatidic acid biosynthetic process
BPTASGO:0006654phosphatidic acid biosynthetic process
BPIEAGO:0008544epidermis development
BPIEAGO:0016024CDP-diacylglycerol biosynthetic process
BPIEAGO:0042493response to drug
BPTASGO:0043312neutrophil degranulation
CCIBAGO:0005783endoplasmic reticulum
CCISSGO:0005783endoplasmic reticulum
CCTASGO:0005789endoplasmic reticulum membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCTASGO:0035579specific granule membrane
MFIBAGO:00038411-acylglycerol-3-phosphate O-acyltransferase activity
MFIDAGO:00038411-acylglycerol-3-phosphate O-acyltransferase activity
MFNASGO:00038411-acylglycerol-3-phosphate O-acyltransferase activity
MFTASGO:00038411-acylglycerol-3-phosphate O-acyltransferase activity

Gene expression in normal tissue: AGPAT2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AGPAT2


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483166Synthesis of PA
reactomeR-HSA-1483206Glycerophospholipid biosynthesis
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-6798695Neutrophil degranulation
wikipathwaysWP236Adipogenesis
wikipathwaysWP325Triacylglyceride Synthesis
kegghsa00561Glycerolipid metabolism - Homo sapiens (human)
kegghsa00564Glycerophospholipid metabolism - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04975Fat digestion and absorption - Homo sapiens (human)
humancycPWY-5667CDP-diacylglycerol biosynthesis
humancycTRIGLSYN-PWYtriacylglycerol biosynthesis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AGPAT2

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