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AIF1

Summary: This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
allograft inflammatory factor 1	MIM:601833	Ensembl:ENSG00000204472	HGNC:HGNC:352	PA24646	6p21.33

Gene Categories:

TUMOR SUPPRESSOR

GO terms in AIF1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	ND	GO:0003674	molecular_function
MF	IBA	GO:0005509	calcium ion binding
MF	ISS	GO:0005509	calcium ion binding
MF	IBA	GO:0051015	actin filament binding
MF	IDA	GO:0051015	actin filament binding
CC	ISS	GO:0001891	phagocytic cup
CC	IDA	GO:0005634	nucleus
CC	ISS	GO:0005634	nucleus
CC	ISS	GO:0005737	cytoplasm
CC	IDA	GO:0005829	cytosol
CC	IBA	GO:0005884	actin filament
CC	IDA	GO:0005884	actin filament
CC	ISS	GO:0030027	lamellipodium
CC	IBA	GO:0032587	ruffle membrane
CC	IDA	GO:0032587	ruffle membrane
CC	IBA	GO:0042995	cell projection
CC	IEA	GO:0043204	perikaryon
CC	IDA	GO:0048471	perinuclear region of cytoplasm
BP	NAS	GO:0001774	microglial cell activation
BP	IEA	GO:0001934	positive regulation of protein phosphorylation
BP	ISS	GO:0006911	phagocytosis, engulfment
BP	ISS	GO:0006954	inflammatory response
BP	NAS	GO:0006954	inflammatory response
BP	IEA	GO:0010629	negative regulation of gene expression
BP	IEA	GO:0014739	positive regulation of muscle hyperplasia
BP	ISS	GO:0016601	Rac protein signal transduction
BP	IEA	GO:0021549	cerebellum development
BP	IDA	GO:0030041	actin filament polymerization
BP	IEA	GO:0031668	cellular response to extracellular stimulus
BP	IEA	GO:0032870	cellular response to hormone stimulus
BP	IDA	GO:0042102	positive regulation of T cell proliferation
BP	IEA	GO:0043066	negative regulation of apoptotic process
BP	IEA	GO:0045429	positive regulation of nitric oxide biosynthetic process
BP	IDA	GO:0048661	positive regulation of smooth muscle cell proliferation
BP	IDA	GO:0048662	negative regulation of smooth muscle cell proliferation
BP	IEA	GO:0048678	response to axon injury
BP	IBA	GO:0051017	actin filament bundle assembly
BP	IDA	GO:0051017	actin filament bundle assembly
BP	IEA	GO:0051384	response to glucocorticoid
BP	IEA	GO:0051602	response to electrical stimulus
BP	IEA	GO:0071315	cellular response to morphine
BP	IEP	GO:0071346	cellular response to interferon-gamma
BP	ISS	GO:0071346	cellular response to interferon-gamma
BP	IEA	GO:0071447	cellular response to hydroperoxide
BP	IDA	GO:0071672	negative regulation of smooth muscle cell chemotaxis
BP	IDA	GO:0071673	positive regulation of smooth muscle cell chemotaxis
BP	IDA	GO:0090026	positive regulation of monocyte chemotaxis
BP	IBA	GO:0097178	ruffle assembly
BP	ISS	GO:0097178	ruffle assembly
BP	NAS	GO:0097178	ruffle assembly
BP	IDA	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
BP	IDA	GO:2000406	positive regulation of T cell migration

Gene expression in normal tissue: AIF1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AIF1

Database	Pathway ID	Pathway Des.
wikipathways	WP2431	Spinal Cord Injury
wikipathways	WP3980	Protein alkylation leading to liver fibrosis

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AIF1

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DATATYPES

CLASSFICATION

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