AJUBA
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ajuba LIM protein | MIM:609066 | Ensembl:ENSG00000129474 | HGNC:HGNC:20250 | PA134978308 | 14q11.2 |
GO terms in AJUBA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000932 | P-body |
| CC | IDA | GO:0000932 | P-body |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005911 | cell-cell junction |
| CC | IDA | GO:0005911 | cell-cell junction |
| CC | IBA | GO:0005912 | adherens junction |
| CC | IEA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0030027 | lamellipodium |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0001666 | response to hypoxia |
| BP | IDA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0007010 | cytoskeleton organization |
| BP | IEA | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| BP | IEA | GO:0030032 | lamellipodium assembly |
| BP | IEA | GO:0030334 | regulation of cell migration |
| BP | IEA | GO:0031328 | positive regulation of cellular biosynthetic process |
| BP | IDA | GO:0031334 | positive regulation of protein complex assembly |
| BP | IEA | GO:0033673 | negative regulation of kinase activity |
| BP | IEA | GO:0034613 | cellular protein localization |
| BP | IMP | GO:0035195 | gene silencing by miRNA |
| BP | IEA | GO:0035313 | wound healing, spreading of epidermal cells |
| BP | IBA | GO:0035329 | hippo signaling |
| BP | IBA | GO:0035331 | negative regulation of hippo signaling |
| BP | IDA | GO:0035331 | negative regulation of hippo signaling |
| BP | IEA | GO:0043087 | regulation of GTPase activity |
| BP | IEA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IEA | GO:0046474 | glycerophospholipid biosynthetic process |
| BP | IEA | GO:0048041 | focal adhesion assembly |
| BP | IDA | GO:1900037 | regulation of cellular response to hypoxia |
| BP | IBA | GO:2000637 | positive regulation of gene silencing by miRNA |
| BP | IMP | GO:2000637 | positive regulation of gene silencing by miRNA |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IBA | GO:0003714 | transcription corepressor activity |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0045294 | alpha-catenin binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0051015 | actin filament binding |
Gene expression in normal tissue: AJUBA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AJUBA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3656 | Interleukin-1 Induced Activation of NF-kappa-B |
| pid | aurora_a_pathway | Aurora A signaling |
| pid | ecadherin_keratinocyte_pathway | E-cadherin signaling in keratinocytes |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04392 | Hippo signaling pathway - multiple species - Homo sapiens (human) |
| reactome | R-HSA-1234174 | Regulation of Hypoxia-inducible Factor (HIF) by oxygen |
| reactome | R-HSA-1234174 | Regulation of Hypoxia-inducible Factor (HIF) by oxygen |
| reactome | R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| reactome | R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2262749 | Cellular response to hypoxia |
| reactome | R-HSA-2262749 | Cellular response to hypoxia |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AJUBA
CLASSFICATION
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