AKR1B10
Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| aldo-keto reductase family 1 member B10 | MIM:604707 | Ensembl:ENSG00000198074 | HGNC:HGNC:382 | PA24676 | 7q33 |
Gene Categories:
DRUGGABLE GENOMEGO terms in AKR1B10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0001523 | retinoid metabolic process |
| BP | IDA | GO:0016488 | farnesol catabolic process |
| BP | IMP | GO:0044597 | daunorubicin metabolic process |
| BP | IMP | GO:0044598 | doxorubicin metabolic process |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005764 | lysosome |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| MF | IDA | GO:0001758 | retinal dehydrogenase activity |
| MF | IBA | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity |
| MF | TAS | GO:0004033 | aldo-keto reductase (NADP) activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008106 | alcohol dehydrogenase (NADP+) activity |
| MF | IBA | GO:0016491 | oxidoreductase activity |
| MF | IDA | GO:0045550 | geranylgeranyl reductase activity |
| MF | IDA | GO:0047718 | indanol dehydrogenase activity |
Gene expression in normal tissue: AKR1B10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AKR1B10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| kegg | hsa00040 | Pentose and glucuronate interconversions - Homo sapiens (human) |
| kegg | hsa00051 | Fructose and mannose metabolism - Homo sapiens (human) |
| kegg | hsa00052 | Galactose metabolism - Homo sapiens (human) |
| kegg | hsa00561 | Glycerolipid metabolism - Homo sapiens (human) |
| kegg | hsa00790 | Folate biosynthesis - Homo sapiens (human) |
| pharmgkb | PA2035 | Cyclophosphamide Pathway, Pharmacodynamics |
| pharmgkb | PA2038 | Ifosfamide Pathway, Pharmacodynamics |
| humancyc | PWY-5451 | acetone degradation I (to methylglyoxal) |
| humancyc | PWY-5453 | methylglyoxal degradation III |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-6806667 | Metabolism of fat-soluble vitamins |
| reactome | R-HSA-975634 | Retinoid metabolism and transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKR1B10
CLASSFICATION
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