AKR1C2
Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| aldo-keto reductase family 1 member C2 | MIM:600450 | Ensembl:ENSG00000151632 | HGNC:HGNC:385 | PA24678 | 10p15.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in AKR1C2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity |
| MF | IDA | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity |
| MF | IBA | GO:0008106 | alcohol dehydrogenase (NADP+) activity |
| MF | IBA | GO:0016229 | steroid dehydrogenase activity |
| MF | IBA | GO:0016491 | oxidoreductase activity |
| MF | IDA | GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| MF | IDA | GO:0018636 | phenanthrene 9,10-monooxygenase activity |
| MF | IDA | GO:0031406 | carboxylic acid binding |
| MF | IDA | GO:0032052 | bile acid binding |
| MF | IBA | GO:0047023 | androsterone dehydrogenase activity |
| MF | IBA | GO:0047086 | ketosteroid monooxygenase activity |
| MF | IDA | GO:0047086 | ketosteroid monooxygenase activity |
| MF | IDA | GO:0047115 | trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| BP | IDA | GO:0006693 | prostaglandin metabolic process |
| BP | IDA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0007586 | digestion |
| BP | IBA | GO:0008202 | steroid metabolic process |
| BP | IDA | GO:0008202 | steroid metabolic process |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEP | GO:0030855 | epithelial cell differentiation |
| BP | IDA | GO:0042448 | progesterone metabolic process |
| BP | IMP | GO:0044597 | daunorubicin metabolic process |
| BP | IMP | GO:0044598 | doxorubicin metabolic process |
| BP | IDA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IDA | GO:0055114 | oxidation-reduction process |
| BP | IDA | GO:0071395 | cellular response to jasmonic acid stimulus |
| BP | IDA | GO:0071799 | cellular response to prostaglandin D stimulus |
Gene expression in normal tissue: AKR1C2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AKR1C2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP696 | Benzo(a)pyrene metabolism |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| wikipathways | WP98 | Prostaglandin Synthesis and Regulation |
| humancyc | PWY-7455 | allopregnanolone biosynthesis |
| kegg | hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-192105 | Synthesis of bile acids and bile salts |
| reactome | R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| reactome | R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| reactome | R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| reactome | R-HSA-194068 | Bile acid and bile salt metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8957322 | Metabolism of steroids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKR1C2
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