AKR1C2


Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
aldo-keto reductase family 1 member C2MIM:600450Ensembl:ENSG00000151632HGNC:HGNC:385PA2467810p15.1

Gene Categories:

DRUGGABLE GENOME

GO terms in AKR1C2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004032alditol:NADP+ 1-oxidoreductase activity
MFIDAGO:0004032alditol:NADP+ 1-oxidoreductase activity
MFIBAGO:0008106alcohol dehydrogenase (NADP+) activity
MFIBAGO:0016229steroid dehydrogenase activity
MFIBAGO:0016491oxidoreductase activity
MFIDAGO:0016655oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
MFIDAGO:0018636phenanthrene 9,10-monooxygenase activity
MFIDAGO:0031406carboxylic acid binding
MFIDAGO:0032052bile acid binding
MFIBAGO:0047023androsterone dehydrogenase activity
MFIBAGO:0047086ketosteroid monooxygenase activity
MFIDAGO:0047086ketosteroid monooxygenase activity
MFIDAGO:0047115trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
CCIEAGO:0005737cytoplasm
CCIBAGO:0005829cytosol
BPIDAGO:0006693prostaglandin metabolic process
BPIDAGO:0007186G-protein coupled receptor signaling pathway
BPIDAGO:0007586digestion
BPIBAGO:0008202steroid metabolic process
BPIDAGO:0008202steroid metabolic process
BPIDAGO:0008284positive regulation of cell proliferation
BPIEPGO:0030855epithelial cell differentiation
BPIDAGO:0042448progesterone metabolic process
BPIMPGO:0044597daunorubicin metabolic process
BPIMPGO:0044598doxorubicin metabolic process
BPIDAGO:0051897positive regulation of protein kinase B signaling
BPIDAGO:0055114oxidation-reduction process
BPIDAGO:0071395cellular response to jasmonic acid stimulus
BPIDAGO:0071799cellular response to prostaglandin D stimulus

Gene expression in normal tissue: AKR1C2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AKR1C2


DatabasePathway IDPathway Des.
wikipathwaysWP696Benzo(a)pyrene metabolism
wikipathwaysWP702Metapathway biotransformation Phase I and II
wikipathwaysWP98Prostaglandin Synthesis and Regulation
humancycPWY-7455allopregnanolone biosynthesis
kegghsa00140Steroid hormone biosynthesis - Homo sapiens (human)
kegghsa05204Chemical carcinogenesis - Homo sapiens (human)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-192105Synthesis of bile acids and bile salts
reactomeR-HSA-193368Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
reactomeR-HSA-193775Synthesis of bile acids and bile salts via 24-hydroxycholesterol
reactomeR-HSA-193807Synthesis of bile acids and bile salts via 27-hydroxycholesterol
reactomeR-HSA-194068Bile acid and bile salt metabolism
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-8957322Metabolism of steroids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AKR1C2

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