AKR1C3
Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| aldo-keto reductase family 1 member C3 | MIM:603966 | Ensembl:ENSG00000196139 | HGNC:HGNC:386 | PA24679 | 10p15.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in AKR1C3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0001758 | retinal dehydrogenase activity |
| MF | IBA | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity |
| MF | IDA | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity |
| MF | TAS | GO:0004033 | aldo-keto reductase (NADP) activity |
| MF | IDA | GO:0004745 | retinol dehydrogenase activity |
| MF | IBA | GO:0005496 | steroid binding |
| MF | IBA | GO:0008106 | alcohol dehydrogenase (NADP+) activity |
| MF | IBA | GO:0016229 | steroid dehydrogenase activity |
| MF | IBA | GO:0016491 | oxidoreductase activity |
| MF | IDA | GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| MF | IDA | GO:0018636 | phenanthrene 9,10-monooxygenase activity |
| MF | IBA | GO:0032052 | bile acid binding |
| MF | IDA | GO:0035410 | dihydrotestosterone 17-beta-dehydrogenase activity |
| MF | TAS | GO:0036130 | prostaglandin H2 endoperoxidase reductase activity |
| MF | TAS | GO:0036131 | prostaglandin D2 11-ketoreductase activity |
| MF | IDA | GO:0045550 | geranylgeranyl reductase activity |
| MF | IDA | GO:0045703 | ketoreductase activity |
| MF | IEA | GO:0047017 | prostaglandin-F synthase activity |
| MF | IDA | GO:0047020 | 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity |
| MF | IBA | GO:0047023 | androsterone dehydrogenase activity |
| MF | IDA | GO:0047023 | androsterone dehydrogenase activity |
| MF | IEA | GO:0047035 | testosterone dehydrogenase (NAD+) activity |
| MF | IEA | GO:0047045 | testosterone 17-beta-dehydrogenase (NADP+) activity |
| MF | IBA | GO:0047086 | ketosteroid monooxygenase activity |
| MF | IDA | GO:0047086 | ketosteroid monooxygenase activity |
| MF | IEA | GO:0047115 | trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity |
| MF | IEA | GO:0047718 | indanol dehydrogenase activity |
| MF | IDA | GO:0047787 | delta4-3-oxosteroid 5beta-reductase activity |
| MF | TAS | GO:0052650 | NADP-retinol dehydrogenase activity |
| BP | IDA | GO:0000060 | protein import into nucleus, translocation |
| BP | TAS | GO:0001523 | retinoid metabolic process |
| BP | IBA | GO:0006693 | prostaglandin metabolic process |
| BP | IEP | GO:0006693 | prostaglandin metabolic process |
| BP | TAS | GO:0006693 | prostaglandin metabolic process |
| BP | IDA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEP | GO:0007584 | response to nutrient |
| BP | IBA | GO:0008202 | steroid metabolic process |
| BP | IEP | GO:0008202 | steroid metabolic process |
| BP | IBA | GO:0008207 | C21-steroid hormone metabolic process |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IEP | GO:0008584 | male gonad development |
| BP | IEP | GO:0009267 | cellular response to starvation |
| BP | IDA | GO:0010942 | positive regulation of cell death |
| BP | IDA | GO:0016488 | farnesol catabolic process |
| BP | TAS | GO:0019371 | cyclooxygenase pathway |
| BP | IEP | GO:0030216 | keratinocyte differentiation |
| BP | IDA | GO:0034614 | cellular response to reactive oxygen species |
| BP | IBA | GO:0042448 | progesterone metabolic process |
| BP | IDA | GO:0042448 | progesterone metabolic process |
| BP | IEA | GO:0042572 | retinol metabolic process |
| BP | IDA | GO:0042574 | retinal metabolic process |
| BP | IEP | GO:0043170 | macromolecule metabolic process |
| BP | IBA | GO:0044597 | daunorubicin metabolic process |
| BP | IMP | GO:0044597 | daunorubicin metabolic process |
| BP | IBA | GO:0044598 | doxorubicin metabolic process |
| BP | IMP | GO:0044598 | doxorubicin metabolic process |
| BP | IDA | GO:0048385 | regulation of retinoic acid receptor signaling pathway |
| BP | IDA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IDA | GO:0055114 | oxidation-reduction process |
| BP | TAS | GO:0055114 | oxidation-reduction process |
| BP | IMP | GO:0061370 | testosterone biosynthetic process |
| BP | NAS | GO:0070293 | renal absorption |
| BP | IDA | GO:0071276 | cellular response to cadmium ion |
| BP | IDA | GO:0071277 | cellular response to calcium ion |
| BP | IDA | GO:0071379 | cellular response to prostaglandin stimulus |
| BP | IDA | GO:0071384 | cellular response to corticosteroid stimulus |
| BP | IDA | GO:0071395 | cellular response to jasmonic acid stimulus |
| BP | IDA | GO:0071799 | cellular response to prostaglandin D stimulus |
| BP | IDA | GO:1900053 | negative regulation of retinoic acid biosynthetic process |
| BP | IMP | GO:2000224 | regulation of testosterone biosynthetic process |
| BP | IDA | GO:2000353 | positive regulation of endothelial cell apoptotic process |
| BP | IDA | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| CC | IDA | GO:0005622 | intracellular |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: AKR1C3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AKR1C3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-192105 | Synthesis of bile acids and bile salts |
| reactome | R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| reactome | R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| reactome | R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| reactome | R-HSA-194068 | Bile acid and bile salt metabolism |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-2142753 | Arachidonic acid metabolism |
| reactome | R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-5362517 | Signaling by Retinoic Acid |
| reactome | R-HSA-5365859 | RA biosynthesis pathway |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-6806667 | Metabolism of fat-soluble vitamins |
| reactome | R-HSA-8957322 | Metabolism of steroids |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-975634 | Retinoid metabolism and transport |
| smpdb | SMP00075 | Arachidonic Acid Metabolism |
| smpdb | SMP00077 | Piroxicam Action Pathway |
| smpdb | SMP00083 | Acetylsalicylic Acid Action Pathway |
| smpdb | SMP00084 | Etodolac Action Pathway |
| smpdb | SMP00085 | Ketoprofen Action Pathway |
| smpdb | SMP00086 | Ibuprofen Action Pathway |
| smpdb | SMP00087 | Rofecoxib Action Pathway |
| smpdb | SMP00093 | Diclofenac Action Pathway |
| smpdb | SMP00094 | Sulindac Action Pathway |
| smpdb | SMP00096 | Celecoxib Action Pathway |
| smpdb | SMP00098 | Ketorolac Action Pathway |
| smpdb | SMP00101 | Suprofen Action Pathway |
| smpdb | SMP00102 | Bromfenac Action Pathway |
| smpdb | SMP00104 | Indomethacin Action Pathway |
| smpdb | SMP00106 | Meloxicam Action Pathway |
| smpdb | SMP00109 | Mefenamic Acid Action Pathway |
| smpdb | SMP00113 | Oxaprozin Action Pathway |
| smpdb | SMP00114 | Nabumetone Action Pathway |
| smpdb | SMP00116 | Valdecoxib Action Pathway |
| smpdb | SMP00120 | Naproxen Action Pathway |
| smpdb | SMP00289 | Diflunisal Action Pathway |
| smpdb | SMP00353 | Leukotriene C4 Synthesis Deficiency |
| smpdb | SMP00650 | Doxorubicin Metabolism Pathway |
| smpdb | SMP00692 | Antipyrine Action Pathway |
| smpdb | SMP00693 | Antrafenine Action Pathway |
| smpdb | SMP00694 | Carprofen Action Pathway |
| smpdb | SMP00695 | Etoricoxib Action Pathway |
| smpdb | SMP00696 | Fenoprofen Action Pathway |
| smpdb | SMP00697 | Flurbiprofen Action Pathway |
| smpdb | SMP00698 | Magnesium salicylate Action Pathway |
| smpdb | SMP00699 | Lumiracoxib Action Pathway |
| smpdb | SMP00700 | Lornoxicam Action Pathway |
| smpdb | SMP00701 | Phenylbutazone Action Pathway |
| smpdb | SMP00702 | Nepafenac Action Pathway |
| smpdb | SMP00703 | Trisalicylate-choline Action Pathway |
| smpdb | SMP00704 | Tolmetin Action Pathway |
| smpdb | SMP00705 | Tiaprofenic Acid Action Pathway |
| smpdb | SMP00706 | Tenoxicam Action Pathway |
| smpdb | SMP00707 | Salsalate Action Pathway |
| smpdb | SMP00708 | Salicylate-sodium Action Pathway |
| smpdb | SMP00709 | Salicylic Acid Action Pathway |
| smpdb | SMP00710 | Acetaminophen Action Pathway |
| wikipathways | WP696 | Benzo(a)pyrene metabolism |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| wikipathways | WP98 | Prostaglandin Synthesis and Regulation |
| pharmgkb | PA152241951 | Celecoxib Pathway, Pharmacodynamics |
| pharmgkb | PA165292164 | Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics |
| pharmgkb | PA165292177 | Doxorubicin Pathway, Pharmacokinetics |
| humancyc | PWY-7305 | superpathway of steroid hormone biosynthesis |
| humancyc | PWY-7455 | allopregnanolone biosynthesis |
| humancyc | PWY66-378 | androgen biosynthesis |
| kegg | hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| kegg | hsa00590 | Arachidonic acid metabolism - Homo sapiens (human) |
| kegg | hsa00790 | Folate biosynthesis - Homo sapiens (human) |
| kegg | hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKR1C3
CLASSFICATION
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