Summary: Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008].

aldehyde dehydrogenase 3 family member A1MIM:100660Ensembl:ENSG00000108602HGNC:HGNC:405PA2469717p11.2

GO terms in ALDH3A1

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:00040283-chloroallyl aldehyde dehydrogenase activity
MFIEAGO:00040283-chloroallyl aldehyde dehydrogenase activity
MFIDAGO:0004029aldehyde dehydrogenase (NAD) activity
MFTASGO:0004030aldehyde dehydrogenase [NAD(P)+] activity
MFIPIGO:0005515protein binding
MFIDAGO:0008106alcohol dehydrogenase (NADP+) activity
MFIDAGO:0018479benzaldehyde dehydrogenase (NAD+) activity
CCHDAGO:0005615extracellular space
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
BPIDAGO:0006081cellular aldehyde metabolic process
BPTASGO:0006805xenobiotic metabolic process
BPIDAGO:0055114oxidation-reduction process

Gene expression in normal tissue: ALDH3A1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ALDH3A1

DatabasePathway IDPathway Des.
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-211945Phase I - Functionalization of compounds
smpdbSMP00006Tyrosine Metabolism
smpdbSMP00039Glycerolipid Metabolism
smpdbSMP00044Histidine Metabolism
smpdbSMP00187Glycerol Kinase Deficiency
smpdbSMP00218Tyrosinemia Type I
smpdbSMP00429Disulfiram Action Pathway
smpdbSMP00447Cyclophosphamide Action Pathway
smpdbSMP00448Ifosfamide Action Pathway
smpdbSMP00494Tyrosinemia, transient, of the newborn
smpdbSMP00498Dopamine beta-hydroxylase deficiency
smpdbSMP00529D-glyceric acidura
smpdbSMP00530Familial lipoprotein lipase deficiency
smpdbSMP00533Monoamine oxidase-a deficiency (MAO-A)
smpdbSMP00604Cyclophosphamide Metabolism Pathway
smpdbSMP00605Ifosfamide Metabolism Pathway
smpdbSMP00633Felbamate Metabolism Pathway
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
pharmgkbPA2035Cyclophosphamide Pathway, Pharmacodynamics
pharmgkbPA2038Ifosfamide Pathway, Pharmacodynamics
humancycPWY-0putrescine degradation III
humancycPWY-71802,-deoxy-α-D-ribose 1-phosphate degradation
kegghsa00010Glycolysis / Gluconeogenesis - Homo sapiens (human)
kegghsa00340Histidine metabolism - Homo sapiens (human)
kegghsa00350Tyrosine metabolism - Homo sapiens (human)
kegghsa00360Phenylalanine metabolism - Homo sapiens (human)
kegghsa00410beta-Alanine metabolism - Homo sapiens (human)
kegghsa00980Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
kegghsa00982Drug metabolism - cytochrome P450 - Homo sapiens (human)
kegghsa05204Chemical carcinogenesis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ALDH3A1