ALDH3A1
Summary: Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 3 family member A1 | MIM:100660 | Ensembl:ENSG00000108602 | HGNC:HGNC:405 | PA24697 | 17p11.2 |
GO terms in ALDH3A1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity |
| MF | IEA | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity |
| MF | IDA | GO:0004029 | aldehyde dehydrogenase (NAD) activity |
| MF | TAS | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008106 | alcohol dehydrogenase (NADP+) activity |
| MF | IDA | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005829 | cytosol |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IDA | GO:0006081 | cellular aldehyde metabolic process |
| BP | TAS | GO:0006805 | xenobiotic metabolic process |
| BP | IDA | GO:0055114 | oxidation-reduction process |
Gene expression in normal tissue: ALDH3A1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ALDH3A1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-211945 | Phase I - Functionalization of compounds |
| smpdb | SMP00006 | Tyrosine Metabolism |
| smpdb | SMP00039 | Glycerolipid Metabolism |
| smpdb | SMP00044 | Histidine Metabolism |
| smpdb | SMP00169 | Alkaptonuria |
| smpdb | SMP00187 | Glycerol Kinase Deficiency |
| smpdb | SMP00190 | Hawkinsinuria |
| smpdb | SMP00191 | Histidinemia |
| smpdb | SMP00218 | Tyrosinemia Type I |
| smpdb | SMP00429 | Disulfiram Action Pathway |
| smpdb | SMP00447 | Cyclophosphamide Action Pathway |
| smpdb | SMP00448 | Ifosfamide Action Pathway |
| smpdb | SMP00494 | Tyrosinemia, transient, of the newborn |
| smpdb | SMP00498 | Dopamine beta-hydroxylase deficiency |
| smpdb | SMP00529 | D-glyceric acidura |
| smpdb | SMP00530 | Familial lipoprotein lipase deficiency |
| smpdb | SMP00533 | Monoamine oxidase-a deficiency (MAO-A) |
| smpdb | SMP00604 | Cyclophosphamide Metabolism Pathway |
| smpdb | SMP00605 | Ifosfamide Metabolism Pathway |
| smpdb | SMP00633 | Felbamate Metabolism Pathway |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| pharmgkb | PA2035 | Cyclophosphamide Pathway, Pharmacodynamics |
| pharmgkb | PA2038 | Ifosfamide Pathway, Pharmacodynamics |
| humancyc | PWY-0 | putrescine degradation III |
| humancyc | PWY-7180 | 2,-deoxy-α-D-ribose 1-phosphate degradation |
| kegg | hsa00010 | Glycolysis / Gluconeogenesis - Homo sapiens (human) |
| kegg | hsa00340 | Histidine metabolism - Homo sapiens (human) |
| kegg | hsa00350 | Tyrosine metabolism - Homo sapiens (human) |
| kegg | hsa00360 | Phenylalanine metabolism - Homo sapiens (human) |
| kegg | hsa00410 | beta-Alanine metabolism - Homo sapiens (human) |
| kegg | hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ALDH3A1
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.