ALDH3A2
Summary: Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 3 family member A2 | MIM:609523 | Ensembl:ENSG00000072210 | HGNC:HGNC:403 | PA24698 | 17p11.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in ALDH3A2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity |
| MF | EXP | GO:0004029 | aldehyde dehydrogenase (NAD) activity |
| MF | IDA | GO:0004029 | aldehyde dehydrogenase (NAD) activity |
| MF | IMP | GO:0004029 | aldehyde dehydrogenase (NAD) activity |
| MF | TAS | GO:0004029 | aldehyde dehydrogenase (NAD) activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0043878 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| MF | IDA | GO:0046577 | long-chain-alcohol oxidase activity |
| MF | IDA | GO:0050061 | long-chain-aldehyde dehydrogenase activity |
| MF | IDA | GO:0052814 | medium-chain-aldehyde dehydrogenase activity |
| CC | TAS | GO:0005778 | peroxisomal membrane |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | TAS | GO:0001561 | fatty acid alpha-oxidation |
| BP | IDA | GO:0006081 | cellular aldehyde metabolic process |
| BP | NAS | GO:0006081 | cellular aldehyde metabolic process |
| BP | IMP | GO:0007417 | central nervous system development |
| BP | IMP | GO:0007422 | peripheral nervous system development |
| BP | IMP | GO:0008544 | epidermis development |
| BP | TAS | GO:0030148 | sphingolipid biosynthetic process |
| BP | IMP | GO:0033306 | phytol metabolic process |
| BP | IDA | GO:0046458 | hexadecanal metabolic process |
| BP | IDA | GO:0055114 | oxidation-reduction process |
Gene expression in normal tissue: ALDH3A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ALDH3A2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00010 | Glycolysis / Gluconeogenesis - Homo sapiens (human) |
| kegg | hsa00053 | Ascorbate and aldarate metabolism - Homo sapiens (human) |
| kegg | hsa00071 | Fatty acid degradation - Homo sapiens (human) |
| kegg | hsa00280 | Valine, leucine and isoleucine degradation - Homo sapiens (human) |
| kegg | hsa00310 | Lysine degradation - Homo sapiens (human) |
| kegg | hsa00330 | Arginine and proline metabolism - Homo sapiens (human) |
| kegg | hsa00340 | Histidine metabolism - Homo sapiens (human) |
| kegg | hsa00380 | Tryptophan metabolism - Homo sapiens (human) |
| kegg | hsa00410 | beta-Alanine metabolism - Homo sapiens (human) |
| kegg | hsa00561 | Glycerolipid metabolism - Homo sapiens (human) |
| kegg | hsa00620 | Pyruvate metabolism - Homo sapiens (human) |
| humancyc | 2PHENDEG-PWY | phenylethylamine degradation I |
| humancyc | PWY-0 | putrescine degradation III |
| humancyc | PWY-6307 | tryptophan degradation via tryptamine |
| humancyc | PWY-6313 | serotonin degradation |
| humancyc | PWY-6342 | noradrenaline and adrenaline degradation |
| humancyc | PWY66-161 | oxidative ethanol degradation III |
| humancyc | PWY66-162 | ethanol degradation IV |
| humancyc | PWY66-21 | ethanol degradation II |
| humancyc | PWY66-387 | fatty acid α-oxidation |
| humancyc | PWY66-388 | fatty acid α-oxidation III |
| humancyc | PWY66-389 | phytol degradation |
| humancyc | PWY66-401 | superpathway of tryptophan utilization |
| humancyc | PWY6666-2 | dopamine degradation |
| smpdb | SMP00450 | Phytanic Acid Peroxisomal Oxidation |
| smpdb | SMP00451 | Refsum Disease |
| wikipathways | WP465 | Tryptophan metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1660661 | Sphingolipid de novo biosynthesis |
| reactome | R-HSA-389599 | Alpha-oxidation of phytanate |
| reactome | R-HSA-390918 | Peroxisomal lipid metabolism |
| reactome | R-HSA-428157 | Sphingolipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ALDH3A2
CLASSFICATION
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