ANTXR2
Summary: This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ANTXR cell adhesion molecule 2 | MIM:608041 | Ensembl:ENSG00000163297 | HGNC:HGNC:21732 | PA128394752 | 4q21.21 |
GO terms in ANTXR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0007165 | signal transduction |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IEA | GO:0022414 | reproductive process |
| BP | IBA | GO:1901998 | toxin transport |
| BP | IEA | GO:1901998 | toxin transport |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IBA | GO:0009986 | cell surface |
| CC | TAS | GO:0010008 | endosome membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0038023 | signaling receptor activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ANTXR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ANTXR2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-5210891 | Uptake and function of anthrax toxins |
| reactome | R-HSA-5339562 | Uptake and actions of bacterial toxins |
| reactome | R-HSA-5663205 | Infectious disease |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| pid | anthraxpathway | Cellular roles of Anthrax toxin |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ANTXR2
CLASSFICATION
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