ANXA1
Summary: This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| annexin A1 | MIM:151690 | Ensembl:ENSG00000135046 | HGNC:HGNC:533 | PA24823 | 9q21.13 |
GO terms in ANXA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003697 | single-stranded DNA binding |
| MF | IEA | GO:0003727 | single-stranded RNA binding |
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IDA | GO:0005198 | structural molecule activity |
| MF | ISS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0005543 | phospholipid binding |
| MF | IDA | GO:0005544 | calcium-dependent phospholipid binding |
| MF | IDA | GO:0019834 | phospholipase A2 inhibitor activity |
| MF | IDA | GO:0030674 | protein binding, bridging |
| MF | IEA | GO:0033676 | double-stranded DNA-dependent ATPase activity |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0048306 | calcium-dependent protein binding |
| MF | HDA | GO:0098641 | cadherin binding involved in cell-cell adhesion |
| MF | IEA | GO:1990814 | DNA/DNA annealing activity |
| CC | IDA | GO:0001533 | cornified envelope |
| CC | IEA | GO:0001891 | phagocytic cup |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005768 | endosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005884 | actin filament |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005913 | cell-cell adherens junction |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0016323 | basolateral plasma membrane |
| CC | ISS | GO:0016324 | apical plasma membrane |
| CC | ISS | GO:0016328 | lateral plasma membrane |
| CC | IDA | GO:0019898 | extrinsic component of membrane |
| CC | IEA | GO:0030659 | cytoplasmic vesicle membrane |
| CC | IDA | GO:0031232 | extrinsic component of external side of plasma membrane |
| CC | ISS | GO:0031313 | extrinsic component of endosome membrane |
| CC | ISS | GO:0031514 | motile cilium |
| CC | ISS | GO:0031901 | early endosome membrane |
| CC | IEA | GO:0031966 | mitochondrial membrane |
| CC | HDA | GO:0031982 | vesicle |
| CC | IEA | GO:0032991 | protein-containing complex |
| CC | IEA | GO:0042383 | sarcolemma |
| CC | IEA | GO:0042629 | mast cell granule |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070062 | extracellular exosome |
| BP | IMP | GO:0001780 | neutrophil homeostasis |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | IDA | GO:0002548 | monocyte chemotaxis |
| BP | ISS | GO:0002685 | regulation of leukocyte migration |
| BP | ISS | GO:0006909 | phagocytosis |
| BP | ISS | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| BP | IMP | GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| BP | IDA | GO:0008360 | regulation of cell shape |
| BP | IEA | GO:0010165 | response to X-ray |
| BP | IEA | GO:0014839 | myoblast migration involved in skeletal muscle regeneration |
| BP | IDA | GO:0018149 | peptide cross-linking |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0030073 | insulin secretion |
| BP | IDA | GO:0030216 | keratinocyte differentiation |
| BP | IEA | GO:0030850 | prostate gland development |
| BP | IEA | GO:0031018 | endocrine pancreas development |
| BP | IDA | GO:0031340 | positive regulation of vesicle fusion |
| BP | IEA | GO:0031394 | positive regulation of prostaglandin biosynthetic process |
| BP | IDA | GO:0031532 | actin cytoskeleton reorganization |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0032508 | DNA duplex unwinding |
| BP | ISS | GO:0032652 | regulation of interleukin-1 production |
| BP | IDA | GO:0032743 | positive regulation of interleukin-2 production |
| BP | IEA | GO:0033031 | positive regulation of neutrophil apoptotic process |
| BP | IDA | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IEA | GO:0042063 | gliogenesis |
| BP | IDA | GO:0042102 | positive regulation of T cell proliferation |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043434 | response to peptide hormone |
| BP | IEA | GO:0044849 | estrous cycle |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IDA | GO:0045627 | positive regulation of T-helper 1 cell differentiation |
| BP | IDA | GO:0045629 | negative regulation of T-helper 2 cell differentiation |
| BP | IMP | GO:0045920 | negative regulation of exocytosis |
| BP | ISS | GO:0046632 | alpha-beta T cell differentiation |
| BP | IMP | GO:0046883 | regulation of hormone secretion |
| BP | IEA | GO:0050482 | arachidonic acid secretion |
| BP | ISS | GO:0050727 | regulation of inflammatory response |
| BP | IEA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IEA | GO:0070365 | hepatocyte differentiation |
| BP | IEA | GO:0070459 | prolactin secretion |
| BP | IEA | GO:0070555 | response to interleukin-1 |
| BP | IDA | GO:0071385 | cellular response to glucocorticoid stimulus |
| BP | IDA | GO:0071621 | granulocyte chemotaxis |
| BP | IDA | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| BP | IDA | GO:0090303 | positive regulation of wound healing |
| BP | IMP | GO:0097350 | neutrophil clearance |
| BP | IEA | GO:0098609 | cell-cell adhesion |
| BP | IEA | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| BP | IEA | GO:1900138 | negative regulation of phospholipase A2 activity |
| BP | IMP | GO:2000483 | negative regulation of interleukin-8 secretion |
Gene expression in normal tissue: ANXA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ANXA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP98 | Prostaglandin Synthesis and Regulation |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-444473 | Formyl peptide receptors bind formyl peptides and many other ligands |
| reactome | R-HSA-445355 | Smooth Muscle Contraction |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-500792 | GPCR ligand binding |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| biocarta | gcrpathway | corticosteroids and cardioprotection |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ANXA1
CLASSFICATION
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