ANXA2
Summary: This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| annexin A2 | MIM:151740 | Ensembl:ENSG00000182718 | HGNC:HGNC:537 | PA24827 | 15q22.2 |
GO terms in ANXA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0001726 | ruffle |
| CC | HDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005604 | basement membrane |
| CC | HDA | GO:0005615 | extracellular space |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005765 | lysosomal membrane |
| CC | IDA | GO:0005768 | endosome |
| CC | IEA | GO:0005769 | early endosome |
| CC | IDA | GO:0005811 | lipid droplet |
| CC | IEA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005913 | cell-cell adherens junction |
| CC | IEA | GO:0005938 | cell cortex |
| CC | IDA | GO:0009986 | cell surface |
| CC | HDA | GO:0016020 | membrane |
| CC | ISS | GO:0016323 | basolateral plasma membrane |
| CC | IEA | GO:0019897 | extrinsic component of plasma membrane |
| CC | IDA | GO:0030496 | midbody |
| CC | IDA | GO:0031902 | late endosome membrane |
| CC | HDA | GO:0031982 | vesicle |
| CC | TAS | GO:0035578 | azurophil granule lumen |
| CC | IEA | GO:0035749 | myelin sheath adaxonal region |
| CC | IEA | GO:0042383 | sarcolemma |
| CC | IEA | GO:0042470 | melanosome |
| CC | IEA | GO:0043220 | Schmidt-Lanterman incisure |
| CC | IEA | GO:0044354 | macropinosome |
| CC | IDA | GO:0045121 | membrane raft |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | ISS | GO:0062023 | collagen-containing extracellular matrix |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:1990667 | PCSK9-AnxA2 complex |
| BP | IEP | GO:0001525 | angiogenesis |
| BP | IMP | GO:0001765 | membrane raft assembly |
| BP | IDA | GO:0001921 | positive regulation of receptor recycling |
| BP | IEA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IMP | GO:0006900 | vesicle budding from membrane |
| BP | IEA | GO:0007589 | body fluid secretion |
| BP | IEA | GO:0030199 | collagen fibril organization |
| BP | IDA | GO:0031340 | positive regulation of vesicle fusion |
| BP | IDA | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process |
| BP | TAS | GO:0035722 | interleukin-12-mediated signaling pathway |
| BP | IDA | GO:0036035 | osteoclast development |
| BP | IEA | GO:0042730 | fibrinolysis |
| BP | IEA | GO:0043086 | negative regulation of catalytic activity |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IMP | GO:0044090 | positive regulation of vacuole organization |
| BP | IMP | GO:0044147 | negative regulation of development of symbiont involved in interaction with host |
| BP | IEA | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | IDA | GO:0051290 | protein heterotetramerization |
| BP | IMP | GO:0052362 | catabolism by host of symbiont protein |
| BP | IMP | GO:0052405 | negative regulation by host of symbiont molecular function |
| BP | IEA | GO:0072659 | protein localization to plasma membrane |
| BP | IEA | GO:0097066 | response to thyroid hormone |
| BP | IEA | GO:0098609 | cell-cell adhesion |
| BP | IDA | GO:1905581 | positive regulation of low-density lipoprotein particle clearance |
| BP | IDA | GO:1905597 | positive regulation of low-density lipoprotein particle receptor binding |
| BP | IMP | GO:1905599 | positive regulation of low-density lipoprotein receptor activity |
| BP | IDA | GO:1905602 | positive regulation of receptor-mediated endocytosis involved in cholesterol transport |
| MF | IPI | GO:0002020 | protease binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005544 | calcium-dependent phospholipid binding |
| MF | IMP | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | IEA | GO:0008092 | cytoskeletal protein binding |
| MF | IEA | GO:0017137 | Rab GTPase binding |
| MF | IDA | GO:0019834 | phospholipase A2 inhibitor activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0044548 | S100 protein binding |
| MF | IEA | GO:0044730 | bone sialoprotein binding |
| MF | IPI | GO:0048306 | calcium-dependent protein binding |
| MF | HDA | GO:0098641 | cadherin binding involved in cell-cell adhesion |
| MF | IDA | GO:0098772 | molecular function regulator |
Gene expression in normal tissue: ANXA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ANXA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-445355 | Smooth Muscle Contraction |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-75205 | Dissolution of Fibrin Clot |
| reactome | R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP4100 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| wikipathways | WP98 | Prostaglandin Synthesis and Regulation |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_TCR | TCR |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ANXA2
CLASSFICATION
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