ANXA4
Summary: Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| annexin A4 | MIM:106491 | Ensembl:ENSG00000196975 | HGNC:HGNC:542 | PA24832 | 2p13.3 |
GO terms in ANXA4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0004859 | phospholipase inhibitor activity |
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005544 | calcium-dependent phospholipid binding |
| MF | NAS | GO:0005544 | calcium-dependent phospholipid binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0048306 | calcium-dependent protein binding |
| MF | IPI | GO:0051059 | NF-kappaB binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0012506 | vesicle membrane |
| CC | IDA | GO:0031965 | nuclear membrane |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IDA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007219 | Notch signaling pathway |
| BP | IEP | GO:0030855 | epithelial cell differentiation |
| BP | IDA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043086 | negative regulation of catalytic activity |
| BP | IMP | GO:2000483 | negative regulation of interleukin-8 secretion |
Gene expression in normal tissue: ANXA4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ANXA4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| wikipathways | WP98 | Prostaglandin Synthesis and Regulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ANXA4
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