AP3B2


Summary: Adaptor protein complex 3 (AP-3 complex) is a heterotrimeric protein complex involved in the formation of clathrin-coated synaptic vesicles. The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. The encoded subunit binds clathrin and is phosphorylated by a casein kinase-like protein, which mediates synaptic vesicle coat assembly. Defects in this gene are a cause of early-onset epileptic encephalopathy. [provided by RefSeq, Feb 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
adaptor related protein complex 3 subunit beta 2MIM:602166Ensembl:ENSG00000103723HGNC:HGNC:567PA2485815q25.2

Gene Categories:

TRANSPORTER

GO terms in AP3B2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006886intracellular protein transport
BPTASGO:0006892post-Golgi vesicle-mediated transport
BPISSGO:0008089anterograde axonal transport
BPISSGO:0048490anterograde synaptic vesicle transport
CCIEAGO:0005794Golgi apparatus
CCIEAGO:0030123AP-3 adaptor complex
CCTASGO:0030137COPI-coated vesicle
CCIEAGO:0030665clathrin-coated vesicle membrane
CCIEAGO:1904115axon cytoplasm
MFTASGO:0005215transporter activity

Gene expression in normal tissue: AP3B2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AP3B2


DatabasePathway IDPathway Des.
kegghsa04142Lysosome - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AP3B2

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