Summary: This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].

amyloid beta precursor like protein 2MIM:104776Ensembl:ENSG00000084234HGNC:HGNC:598PA2488511q24.3

GO terms in APLP2

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0002576platelet degranulation
BPNASGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0010951negative regulation of endopeptidase activity
BPTASGO:0043687post-translational protein modification
BPTASGO:0044267cellular protein metabolic process
CCTASGO:0005788endoplasmic reticulum lumen
CCTASGO:0005886plasma membrane
CCNASGO:0016021integral component of membrane
CCTASGO:0031092platelet alpha granule membrane
CCHDAGO:0070062extracellular exosome
MFNASGO:0003677DNA binding
MFIEAGO:0004867serine-type endopeptidase inhibitor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008201heparin binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0046914transition metal ion binding

Gene expression in normal tissue: APLP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in APLP2

DatabasePathway IDPathway Des.
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-8957275Post-translational protein phosphorylation
wikipathwaysWP4148Splicing factor NOVA regulated synaptic proteins

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in APLP2