APOBEC3B
Summary: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| apolipoprotein B mRNA editing enzyme catalytic subunit 3B | MIM:607110 | Ensembl:ENSG00000179750 | HGNC:HGNC:17352 | PA24892 | 22q13.1 |
GO terms in APOBEC3B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IBA | GO:0004126 | cytidine deaminase activity |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IMP | GO:0047844 | deoxycytidine deaminase activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| BP | IDA | GO:0010529 | negative regulation of transposition |
| BP | IBA | GO:0016554 | cytidine to uridine editing |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IDA | GO:0051607 | defense response to virus |
| BP | IBA | GO:0080111 | DNA demethylation |
Gene expression in normal tissue: APOBEC3B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in APOBEC3B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-72200 | mRNA Editing: C to U Conversion |
| reactome | R-HSA-75072 | mRNA Editing |
| reactome | R-HSA-75094 | Formation of the Editosome |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in APOBEC3B
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