APOBEC3C


Summary: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
apolipoprotein B mRNA editing enzyme catalytic subunit 3CMIM:607750Ensembl:ENSG00000244509HGNC:HGNC:17353PA2489322q13.1

GO terms in APOBEC3C


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIBAGO:0003723RNA binding
MFIBAGO:0004126cytidine deaminase activity
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIEAGO:0016814hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
MFIBAGO:0047844deoxycytidine deaminase activity
BPIDAGO:0009972cytidine deamination
BPIBAGO:0010529negative regulation of transposition
BPIDAGO:0010529negative regulation of transposition
BPIEAGO:0016032viral process
BPIBAGO:0016554cytidine to uridine editing
BPIDAGO:0045071negative regulation of viral genome replication
BPIEAGO:0045087innate immune response
BPIBAGO:0045869negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
BPIBAGO:0051607defense response to virus
BPIEAGO:0051607defense response to virus
BPIBAGO:0070383DNA cytosine deamination
BPIBAGO:0080111DNA demethylation
BPIDAGO:0080111DNA demethylation
CCIBAGO:0000932P-body
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm

Gene expression in normal tissue: APOBEC3C

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in APOBEC3C


DatabasePathway IDPathway Des.
reactomeR-HSA-72200mRNA Editing: C to U Conversion
reactomeR-HSA-75072mRNA Editing
reactomeR-HSA-75094Formation of the Editosome
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in APOBEC3C

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