APOBEC3C
Summary: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| apolipoprotein B mRNA editing enzyme catalytic subunit 3C | MIM:607750 | Ensembl:ENSG00000244509 | HGNC:HGNC:17353 | PA24893 | 22q13.1 |
GO terms in APOBEC3C
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IBA | GO:0004126 | cytidine deaminase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines |
| MF | IBA | GO:0047844 | deoxycytidine deaminase activity |
| BP | IDA | GO:0009972 | cytidine deamination |
| BP | IBA | GO:0010529 | negative regulation of transposition |
| BP | IDA | GO:0010529 | negative regulation of transposition |
| BP | IEA | GO:0016032 | viral process |
| BP | IBA | GO:0016554 | cytidine to uridine editing |
| BP | IDA | GO:0045071 | negative regulation of viral genome replication |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IBA | GO:0045869 | negative regulation of single stranded viral RNA replication via double stranded DNA intermediate |
| BP | IBA | GO:0051607 | defense response to virus |
| BP | IEA | GO:0051607 | defense response to virus |
| BP | IBA | GO:0070383 | DNA cytosine deamination |
| BP | IBA | GO:0080111 | DNA demethylation |
| BP | IDA | GO:0080111 | DNA demethylation |
| CC | IBA | GO:0000932 | P-body |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: APOBEC3C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in APOBEC3C
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-72200 | mRNA Editing: C to U Conversion |
| reactome | R-HSA-75072 | mRNA Editing |
| reactome | R-HSA-75094 | Formation of the Editosome |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in APOBEC3C
CLASSFICATION
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