APOBR
Summary: Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
apolipoprotein B receptor | MIM:605220 | Ensembl:ENSG00000184730 | HGNC:HGNC:24087 | PA166048957 | 16p12.1 |
GO terms in APOBR
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IBA | GO:0006641 | triglyceride metabolic process |
BP | IEA | GO:0006869 | lipid transport |
BP | IEA | GO:0008203 | cholesterol metabolic process |
BP | TAS | GO:0034447 | very-low-density lipoprotein particle clearance |
CC | TAS | GO:0005886 | plasma membrane |
CC | HDA | GO:0016020 | membrane |
CC | IEA | GO:0034361 | very-low-density lipoprotein particle |
CC | IEA | GO:0034362 | low-density lipoprotein particle |
CC | IEA | GO:0042627 | chylomicron |
MF | IBA | GO:0030229 | very-low-density lipoprotein particle receptor activity |
Gene expression in normal tissue: APOBR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in APOBR
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
reactome | R-HSA-382551 | Transport of small molecules |
reactome | R-HSA-8964043 | Plasma lipoprotein clearance |
reactome | R-HSA-8964046 | VLDL clearance |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in APOBR