APOC1
Summary: This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| apolipoprotein C1 | MIM:107710 | Ensembl:ENSG00000130208 | HGNC:HGNC:607 | PA51 | 19q13.32 |
GO terms in APOC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006629 | lipid metabolic process |
| BP | IEA | GO:0006641 | triglyceride metabolic process |
| BP | IEA | GO:0008203 | cholesterol metabolic process |
| BP | TAS | GO:0010873 | positive regulation of cholesterol esterification |
| BP | IDA | GO:0010900 | negative regulation of phosphatidylcholine catabolic process |
| BP | IDA | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance |
| BP | IC | GO:0032374 | regulation of cholesterol transport |
| BP | IDA | GO:0032375 | negative regulation of cholesterol transport |
| BP | IDA | GO:0033344 | cholesterol efflux |
| BP | IDA | GO:0033700 | phospholipid efflux |
| BP | IDA | GO:0034369 | plasma lipoprotein particle remodeling |
| BP | TAS | GO:0034375 | high-density lipoprotein particle remodeling |
| BP | TAS | GO:0034379 | very-low-density lipoprotein particle assembly |
| BP | IDA | GO:0034382 | chylomicron remnant clearance |
| BP | IGI | GO:0034447 | very-low-density lipoprotein particle clearance |
| BP | TAS | GO:0034447 | very-low-density lipoprotein particle clearance |
| BP | IEA | GO:0042157 | lipoprotein metabolic process |
| BP | IEA | GO:0043085 | positive regulation of catalytic activity |
| BP | IDA | GO:0045717 | negative regulation of fatty acid biosynthetic process |
| BP | IDA | GO:0045833 | negative regulation of lipid metabolic process |
| BP | IDA | GO:0048261 | negative regulation of receptor-mediated endocytosis |
| BP | IDA | GO:0050995 | negative regulation of lipid catabolic process |
| BP | IDA | GO:0051005 | negative regulation of lipoprotein lipase activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0034361 | very-low-density lipoprotein particle |
| CC | IDA | GO:0034364 | high-density lipoprotein particle |
| CC | TAS | GO:0042627 | chylomicron |
| MF | IDA | GO:0004859 | phospholipase inhibitor activity |
| MF | IDA | GO:0005504 | fatty acid binding |
| MF | TAS | GO:0031210 | phosphatidylcholine binding |
| MF | IDA | GO:0055102 | lipase inhibitor activity |
| MF | TAS | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity |
Gene expression in normal tissue: APOC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in APOC1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
| pharmgkb | PA2031 | Statin Pathway, Pharmacodynamics |
| wikipathways | WP430 | Statin Pathway |
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-8866423 | VLDL assembly |
| reactome | R-HSA-8963898 | Plasma lipoprotein assembly |
| reactome | R-HSA-8964043 | Plasma lipoprotein clearance |
| reactome | R-HSA-8964043 | Plasma lipoprotein clearance |
| reactome | R-HSA-8964046 | VLDL clearance |
| reactome | R-HSA-8964046 | VLDL clearance |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in APOC1
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