APOC2
Summary: This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| apolipoprotein C2 | MIM:608083 | Ensembl:ENSG00000234906 | HGNC:HGNC:609 | PA52 | 19q13.32 |
GO terms in APOC2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0008289 | lipid binding |
| MF | IDA | GO:0008289 | lipid binding |
| MF | IBA | GO:0016004 | phospholipase activator activity |
| MF | IDA | GO:0016004 | phospholipase activator activity |
| MF | IMP | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0043274 | phospholipase binding |
| MF | IPI | GO:0043274 | phospholipase binding |
| MF | IDA | GO:0055102 | lipase inhibitor activity |
| MF | IBA | GO:0060230 | lipoprotein lipase activator activity |
| MF | IDA | GO:0060230 | lipoprotein lipase activator activity |
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005769 | early endosome |
| CC | IBA | GO:0034361 | very-low-density lipoprotein particle |
| CC | IDA | GO:0034361 | very-low-density lipoprotein particle |
| CC | IBA | GO:0034362 | low-density lipoprotein particle |
| CC | IDA | GO:0034362 | low-density lipoprotein particle |
| CC | IBA | GO:0034363 | intermediate-density lipoprotein particle |
| CC | IDA | GO:0034363 | intermediate-density lipoprotein particle |
| CC | IBA | GO:0034366 | spherical high-density lipoprotein particle |
| CC | IDA | GO:0034366 | spherical high-density lipoprotein particle |
| CC | IBA | GO:0042627 | chylomicron |
| CC | IDA | GO:0042627 | chylomicron |
| BP | TAS | GO:0001523 | retinoid metabolic process |
| BP | IBA | GO:0010518 | positive regulation of phospholipase activity |
| BP | IDA | GO:0010518 | positive regulation of phospholipase activity |
| BP | IDA | GO:0010898 | positive regulation of triglyceride catabolic process |
| BP | IC | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling |
| BP | IBA | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance |
| BP | IDA | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance |
| BP | IEA | GO:0016042 | lipid catabolic process |
| BP | IMP | GO:0032375 | negative regulation of cholesterol transport |
| BP | IDA | GO:0033344 | cholesterol efflux |
| BP | IDA | GO:0033700 | phospholipid efflux |
| BP | TAS | GO:0034370 | triglyceride-rich lipoprotein particle remodeling |
| BP | IC | GO:0034371 | chylomicron remodeling |
| BP | TAS | GO:0034371 | chylomicron remodeling |
| BP | TAS | GO:0034372 | very-low-density lipoprotein particle remodeling |
| BP | TAS | GO:0034375 | high-density lipoprotein particle remodeling |
| BP | TAS | GO:0034378 | chylomicron assembly |
| BP | IBA | GO:0034382 | chylomicron remnant clearance |
| BP | IDA | GO:0034382 | chylomicron remnant clearance |
| BP | IBA | GO:0034384 | high-density lipoprotein particle clearance |
| BP | IMP | GO:0034384 | high-density lipoprotein particle clearance |
| BP | IBA | GO:0042159 | lipoprotein catabolic process |
| BP | IEA | GO:0042493 | response to drug |
| BP | IC | GO:0042632 | cholesterol homeostasis |
| BP | IEA | GO:0042953 | lipoprotein transport |
| BP | IEA | GO:0043086 | negative regulation of catalytic activity |
| BP | IC | GO:0043691 | reverse cholesterol transport |
| BP | IDA | GO:0045723 | positive regulation of fatty acid biosynthetic process |
| BP | IDA | GO:0045833 | negative regulation of lipid metabolic process |
| BP | IDA | GO:0048261 | negative regulation of receptor-mediated endocytosis |
| BP | IBA | GO:0051006 | positive regulation of lipoprotein lipase activity |
| BP | IDA | GO:0051006 | positive regulation of lipoprotein lipase activity |
| BP | IBA | GO:0060697 | positive regulation of phospholipid catabolic process |
| BP | IDA | GO:0060697 | positive regulation of phospholipid catabolic process |
| BP | IMP | GO:0070328 | triglyceride homeostasis |
Gene expression in normal tissue: APOC2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in APOC2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-6806667 | Metabolism of fat-soluble vitamins |
| reactome | R-HSA-6806667 | Metabolism of fat-soluble vitamins |
| reactome | R-HSA-8963888 | Chylomicron assembly |
| reactome | R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes |
| reactome | R-HSA-8963898 | Plasma lipoprotein assembly |
| reactome | R-HSA-8963899 | Plasma lipoprotein remodeling |
| reactome | R-HSA-8963899 | Plasma lipoprotein remodeling |
| reactome | R-HSA-8963901 | Chylomicron remodeling |
| reactome | R-HSA-8964058 | HDL remodeling |
| reactome | R-HSA-975634 | Retinoid metabolism and transport |
| reactome | R-HSA-975634 | Retinoid metabolism and transport |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| wikipathways | WP4129 | Plasma lipoprotein assembly, remodeling, and clearance |
| wikipathways | WP430 | Statin Pathway |
| kegg | hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
| pharmgkb | PA2031 | Statin Pathway, Pharmacodynamics |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in APOC2
CLASSFICATION
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