Summary: This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010].

ADP ribosylation factor 5MIM:103188Ensembl:ENSG00000004059HGNC:HGNC:658PA249417q32.1

GO terms in ARF5

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003924GTPase activity
MFIPIGO:0005515protein binding
MFIBAGO:0005525GTP binding
MFIEAGO:0005525GTP binding
BPIBAGO:0006886intracellular protein transport
BPIBAGO:0006890retrograde vesicle-mediated transport, Golgi to ER
BPIGIGO:0006890retrograde vesicle-mediated transport, Golgi to ER
BPIBAGO:0006893Golgi to plasma membrane transport
BPIEAGO:0015031protein transport
BPIBAGO:0016192vesicle-mediated transport
CCIBAGO:0005794Golgi apparatus
CCIEAGO:0005794Golgi apparatus
CCIBAGO:0005886plasma membrane
CCIEAGO:0005886plasma membrane
CCIEAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: ARF5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARF5

DatabasePathway IDPathway Des.
pidpi3kcipathwayClass I PI3K signaling events
kegghsa04144Endocytosis - Homo sapiens (human)
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6807878COPI-mediated anterograde transport
reactomeR-HSA-6811434COPI-dependent Golgi-to-ER retrograde traffic
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic
reactomeR-HSA-8856688Golgi-to-ER retrograde transport
reactomeR-HSA-948021Transport to the Golgi and subsequent modification

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARF5