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ARHGAP12

Summary: This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Rho GTPase activating protein 12	MIM:610577	Ensembl:ENSG00000165322	HGNC:HGNC:16348	PA24957	10p11.22

GO terms in ARHGAP12

Term Type	Evidence Type	GO Term ID	GO Des.
MF	TAS	GO:0005096	GTPase activator activity
CC	IDA	GO:0001891	phagocytic cup
CC	IBA	GO:0005737	cytoplasm
CC	TAS	GO:0005829	cytosol
BP	IMP	GO:0002011	morphogenesis of an epithelial sheet
BP	IMP	GO:0006911	phagocytosis, engulfment
BP	IMP	GO:0007015	actin filament organization
BP	IEA	GO:0007165	signal transduction
BP	IBA	GO:0043087	regulation of GTPase activity
BP	IEA	GO:0043547	positive regulation of GTPase activity
BP	TAS	GO:0051056	regulation of small GTPase mediated signal transduction
BP	IMP	GO:0051058	negative regulation of small GTPase mediated signal transduction

Gene expression in normal tissue: ARHGAP12

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARHGAP12

Database	Pathway ID	Pathway Des.
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-194315	Signaling by Rho GTPases
reactome	R-HSA-194840	Rho GTPase cycle

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARHGAP12

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