ARHGAP18
Summary: ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Rho GTPase activating protein 18 | MIM:613351 | Ensembl:ENSG00000146376 | HGNC:HGNC:21035 | PA134884487 | 6q22.33 |
GO terms in ARHGAP18
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005096 | GTPase activator activity |
| MF | IMP | GO:0005096 | GTPase activator activity |
| MF | TAS | GO:0005096 | GTPase activator activity |
| MF | HDA | GO:0045296 | cadherin binding |
| BP | IMP | GO:0007264 | small GTPase mediated signal transduction |
| BP | IMP | GO:0008360 | regulation of cell shape |
| BP | IBA | GO:0030833 | regulation of actin filament polymerization |
| BP | IMP | GO:0030833 | regulation of actin filament polymerization |
| BP | IBA | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IMP | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | IBA | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IMP | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IMP | GO:2000145 | regulation of cell motility |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IMP | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0016607 | nuclear speck |
Gene expression in normal tissue: ARHGAP18
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARHGAP18
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARHGAP18
CLASSFICATION
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