Summary: This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Rho GTPase activating protein 6MIM:300118Ensembl:ENSG00000047648HGNC:HGNC:676PA24960Xp22.2

GO terms in ARHGAP6

Term TypeEvidence TypeGO Term IDGO Des.
BPNASGO:0007266Rho protein signal transduction
BPIEAGO:0009967positive regulation of signal transduction
BPNASGO:0030041actin filament polymerization
BPIEAGO:0043547positive regulation of GTPase activity
BPIEAGO:0048041focal adhesion assembly
BPTASGO:0051056regulation of small GTPase mediated signal transduction
BPIMPGO:0051497negative regulation of stress fiber assembly
BPIMPGO:0051895negative regulation of focal adhesion assembly
CCNASGO:0005884actin filament
CCISSGO:0015629actin cytoskeleton
MFTASGO:0005070SH3/SH2 adaptor activity
MFTASGO:0005096GTPase activator activity
MFIEAGO:0017124SH3 domain binding

Gene expression in normal tissue: ARHGAP6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARHGAP6

DatabasePathway IDPathway Des.
pidrhoa_reg_pathwayRegulation of RhoA activity
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle
biocartaarappathwayadp-ribosylation factor
biocartarac1pathwayrac1 cell motility signaling pathway
biocartarhopathwayrho cell motility signaling pathway
biocartatcrpathwayt cell receptor signaling pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARHGAP6