ASH1L


Summary: This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ASH1 like histone lysine methyltransferaseMIM:607999Ensembl:ENSG00000116539HGNC:HGNC:19088PA1348910641q22

GO terms in ASH1L


Term TypeEvidence TypeGO Term IDGO Des.
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
MFIEAGO:0003682chromatin binding
MFTASGO:0018024histone-lysine N-methyltransferase activity
MFIEAGO:0042800histone methyltransferase activity (H3-K4 specific)
MFIEAGO:0046872metal ion binding
MFIDAGO:0046975histone methyltransferase activity (H3-K36 specific)
CCTASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005694chromosome
CCIDAGO:0005794Golgi apparatus
CCIEAGO:0005923bicellular tight junction
BPIEAGO:0001501skeletal system development
BPIEAGO:0002674negative regulation of acute inflammatory response
BPTASGO:0006323DNA packaging
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0007267cell-cell signaling
BPIEAGO:0007338single fertilization
BPIEAGO:0009791post-embryonic development
BPIEAGO:0032635interleukin-6 production
BPIEAGO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043409negative regulation of MAPK cascade
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046697decidualization
BPIEAGO:0051568histone H3-K4 methylation
BPIEAGO:0061038uterus morphogenesis
BPIDAGO:0097676histone H3-K36 dimethylation
BPIEAGO:0097722sperm motility
BPIEAGO:1903699tarsal gland development
BPIEAGO:1903709uterine gland development

Gene expression in normal tissue: ASH1L

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ASH1L


DatabasePathway IDPathway Des.
reactomeR-HSA-3214841PKMTs methylate histone lysines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization
wikipathwaysWP2369Histone Modifications
kegghsa00310Lysine degradation - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD179Shikonin2
iGMDRD293Bleomycin1
iGMDRD292NSC878772
iGMDRD391OSU-030121

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ASH1L

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