Summary: This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012].

acid sensing ion channel subunit 2MIM:601784Ensembl:ENSG00000108684HGNC:HGNC:99PA2443317q11.2-q12

GO terms in ASIC2

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFTASGO:0015280ligand-gated sodium channel activity
MFTASGO:0044736acid-sensing ion channel activity
CCTASGO:0005886plasma membrane
CCIEAGO:0005887integral component of plasma membrane
CCIEAGO:0043025neuronal cell body
CCIEAGO:0043197dendritic spine
BPIEAGO:0003026regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
BPTASGO:0007268chemical synaptic transmission
BPTASGO:0007417central nervous system development
BPTASGO:0007422peripheral nervous system development
BPIEAGO:0007605sensory perception of sound
BPIEAGO:0010447response to acidic pH
BPTASGO:0015672monovalent inorganic cation transport
BPIEAGO:0019229regulation of vasoconstriction
BPTASGO:0034220ion transmembrane transport
BPIEAGO:0034765regulation of ion transmembrane transport
BPIEAGO:0035418protein localization to synapse
BPIEAGO:0035725sodium ion transmembrane transport
BPIEAGO:0042391regulation of membrane potential
BPIEAGO:0043066negative regulation of apoptotic process
BPIMPGO:0050915sensory perception of sour taste
BPIEAGO:0050974detection of mechanical stimulus involved in sensory perception
BPIEAGO:0051965positive regulation of synapse assembly

Gene expression in normal tissue: ASIC2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ASIC2

DatabasePathway IDPathway Des.
reactomeR-HSA-2672351Stimuli-sensing channels
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-983712Ion channel transport
kegghsa04742Taste transduction - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ASIC2