ATP1B1


Summary: The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ATPase Na+/K+ transporting subunit beta 1MIM:182330Ensembl:ENSG00000143153HGNC:HGNC:804PA661q24.2

GO terms in ATP1B1


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0001671ATPase activator activity
MFIDAGO:0001671ATPase activator activity
MFIBAGO:0005391sodium:potassium-exchanging ATPase activity
MFIDAGO:0005391sodium:potassium-exchanging ATPase activity
MFISSGO:0005391sodium:potassium-exchanging ATPase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIEAGO:0008022protein C-terminus binding
MFIPIGO:0008144drug binding
MFIDAGO:0016887ATPase activity
MFIEAGO:0019901protein kinase binding
MFHDAGO:0023026MHC class II protein complex binding
MFIDAGO:0030955potassium ion binding
MFIDAGO:0031402sodium ion binding
MFIPIGO:0051117ATPase binding
CCIEAGO:0005622intracellular
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005890sodium:potassium-exchanging ATPase complex
CCIDAGO:0005890sodium:potassium-exchanging ATPase complex
CCISSGO:0005890sodium:potassium-exchanging ATPase complex
CCIEAGO:0005901caveola
CCISSGO:0014704intercalated disc
CCIDAGO:0016020membrane
CCIEAGO:0016323basolateral plasma membrane
CCIEAGO:0016324apical plasma membrane
CCISSGO:0042383sarcolemma
CCIEAGO:0043209myelin sheath
CCHDAGO:0070062extracellular exosome
CCHDAGO:1903561extracellular vesicle
BPIEAGO:0001666response to hypoxia
BPISSGO:0006874cellular calcium ion homeostasis
BPIBAGO:0006883cellular sodium ion homeostasis
BPIDAGO:0006883cellular sodium ion homeostasis
BPIEAGO:0007155cell adhesion
BPIBAGO:0010107potassium ion import
BPIDAGO:0010107potassium ion import
BPIEAGO:0010248establishment or maintenance of transmembrane electrochemical gradient
BPISSGO:0010468regulation of gene expression
BPISSGO:0010882regulation of cardiac muscle contraction by calcium ion signaling
BPIBAGO:0030007cellular potassium ion homeostasis
BPIDAGO:0030007cellular potassium ion homeostasis
BPIDAGO:0032781positive regulation of ATPase activity
BPIBAGO:0036376sodium ion export across plasma membrane
BPIDAGO:0036376sodium ion export across plasma membrane
BPISSGO:0036376sodium ion export across plasma membrane
BPTASGO:0044861protein transport into plasma membrane raft
BPIDAGO:0046034ATP metabolic process
BPIDAGO:0050821protein stabilization
BPISSGO:0050821protein stabilization
BPTASGO:0050900leukocyte migration
BPISSGO:0055119relaxation of cardiac muscle
BPISSGO:0060048cardiac muscle contraction
BPIDAGO:0072659protein localization to plasma membrane
BPIDAGO:0086009membrane repolarization
BPICGO:0086013membrane repolarization during cardiac muscle cell action potential
BPTASGO:0086064cell communication by electrical coupling involved in cardiac conduction
BPIDAGO:1901018positive regulation of potassium ion transmembrane transporter activity
BPIDAGO:1903278positive regulation of sodium ion export across plasma membrane
BPISSGO:1903281positive regulation of calcium:sodium antiporter activity
BPIDAGO:1903288positive regulation of potassium ion import
BPISSGO:1990573potassium ion import across plasma membrane

Gene expression in normal tissue: ATP1B1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATP1B1


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-210991Basigin interactions
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5578775Ion homeostasis
reactomeR-HSA-936837Ion transport by P-type ATPases
reactomeR-HSA-983712Ion channel transport
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04260Cardiac muscle contraction - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04960Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
kegghsa04961Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
kegghsa04964Proximal tubule bicarbonate reclamation - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
kegghsa04971Gastric acid secretion - Homo sapiens (human)
kegghsa04972Pancreatic secretion - Homo sapiens (human)
kegghsa04973Carbohydrate digestion and absorption - Homo sapiens (human)
kegghsa04974Protein digestion and absorption - Homo sapiens (human)
kegghsa04976Bile secretion - Homo sapiens (human)
kegghsa04978Mineral absorption - Homo sapiens (human)
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
smpdbSMP00078Chlorothiazide Action Pathway
smpdbSMP00080Polythiazide Action Pathway
smpdbSMP00081Methyclothiazide Action Pathway
smpdbSMP00088Bumetanide Action Pathway
smpdbSMP00090Bendroflumethiazide Action Pathway
smpdbSMP00091Quinethazone Action Pathway
smpdbSMP00097Ethacrynic Acid Action Pathway
smpdbSMP00100Hydrochlorothiazide Action Pathway
smpdbSMP00103Cyclothiazide Action Pathway
smpdbSMP00105Metolazone Action Pathway
smpdbSMP00108Hydroflumethiazide Action Pathway
smpdbSMP00110Indapamide Action Pathway
smpdbSMP00115Furosemide Action Pathway
smpdbSMP00118Torsemide Action Pathway
smpdbSMP00121Trichlormethiazide Action Pathway
smpdbSMP00122Chlorthalidone Action Pathway
smpdbSMP00132Triamterene Action Pathway
smpdbSMP00133Amiloride Action Pathway
smpdbSMP00134Spironolactone Action Pathway
smpdbSMP00135Eplerenone Action Pathway
smpdbSMP00184Glucose Transporter Defect (SGLT2)
smpdbSMP00189Hartnup Disorder
smpdbSMP00193Iminoglycinuria
smpdbSMP00197Lysinuric Protein Intolerance
smpdbSMP00245Glucose Transporter Defect (SGLT2)
smpdbSMP00296Acebutolol Action Pathway
smpdbSMP00297Alprenolol Action Pathway
smpdbSMP00298Atenolol Action Pathway
smpdbSMP00299Betaxolol Action Pathway
smpdbSMP00300Bisoprolol Action Pathway
smpdbSMP00301Esmolol Action Pathway
smpdbSMP00302Metoprolol Action Pathway
smpdbSMP00303Nadolol Action Pathway
smpdbSMP00304Oxprenolol Action Pathway
smpdbSMP00305Penbutolol Action Pathway
smpdbSMP00306Pindolol Action Pathway
smpdbSMP00307Propranolol Action Pathway
smpdbSMP00323Quinidine Action Pathway
smpdbSMP00324Procainamide (Antiarrhythmic) Action Pathway
smpdbSMP00325Disopyramide Action Pathway
smpdbSMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00328Lidocaine (Antiarrhythmic) Action Pathway
smpdbSMP00329Mexiletine Action Pathway
smpdbSMP00330Tocainide Action Pathway
smpdbSMP00331Flecainide Action Pathway
smpdbSMP00332Ibutilide Action Pathway
smpdbSMP00359Diltiazem Action Pathway
smpdbSMP00366Nebivolol Action Pathway
smpdbSMP00367Carvedilol Action Pathway
smpdbSMP00368Labetalol Action Pathway
smpdbSMP00375Verapamil Action Pathway
smpdbSMP00376Amlodipine Action Pathway
smpdbSMP00377Felodipine Action Pathway
smpdbSMP00378Isradipine Action Pathway
smpdbSMP00379Nifedipine Action Pathway
smpdbSMP00380Nimodipine Action Pathway
smpdbSMP00381Nisoldipine Action Pathway
smpdbSMP00382Nitrendipine Action Pathway
smpdbSMP00392Benzocaine Action Pathway
smpdbSMP00393Bupivacaine Action Pathway
smpdbSMP00394Chloroprocaine Action Pathway
smpdbSMP00395Cocaine Action Pathway
smpdbSMP00396Dibucaine Action Pathway
smpdbSMP00397Levobupivacaine Action Pathway
smpdbSMP00398Lidocaine (Local Anaesthetic) Action Pathway
smpdbSMP00399Mepivacaine Action Pathway
smpdbSMP00400Oxybuprocaine Action Pathway
smpdbSMP00401Prilocaine Action Pathway
smpdbSMP00402Procaine Action Pathway
smpdbSMP00403Proparacaine Action Pathway
smpdbSMP00404Ropivacaine Action Pathway
smpdbSMP00405Codeine Action Pathway
smpdbSMP00406Morphine Action Pathway
smpdbSMP00407Heroin Action Pathway
smpdbSMP00408Methadone Action Pathway
smpdbSMP00409Oxycodone Action Pathway
smpdbSMP00410Hydromorphone Action Pathway
smpdbSMP00411Hydrocodone Action Pathway
smpdbSMP00412Oxymorphone Action Pathway
smpdbSMP00413Alfentanil Action Pathway
smpdbSMP00414Carfentanil Action Pathway
smpdbSMP00415Fentanyl Action Pathway
smpdbSMP00416Remifentanil Action Pathway
smpdbSMP00417Sufentanil Action Pathway
smpdbSMP00422Imipramine Action Pathway
smpdbSMP00423Desipramine Action Pathway
smpdbSMP00424Citalopram Action Pathway
smpdbSMP00425Escitalopram Action Pathway
smpdbSMP00426Fluoxetine Action Pathway
smpdbSMP00431Nicotine Action Pathway
smpdbSMP00457Lactose Degradation
smpdbSMP00458Lactose Intolerance
smpdbSMP00467Trehalose Degradation
smpdbSMP00483Kidney Function
smpdbSMP00583Blue diaper syndrome
smpdbSMP00585Lysinuric protein intolerance (LPI)
smpdbSMP00588Muscle/Heart Contraction
smpdbSMP00657Bopindolol Action Pathway
smpdbSMP00658Carteolol Action Pathway
smpdbSMP00659Timolol Action Pathway
smpdbSMP00660Sotalol Action Pathway
smpdbSMP00661Epinephrine Action Pathway
smpdbSMP00662Dobutamine Action Pathway
smpdbSMP00663Isoprenaline Action Pathway
smpdbSMP00664Arbutamine Action Pathway
smpdbSMP00665Amiodarone Action Pathway
smpdbSMP00666Levobunolol Action Pathway
smpdbSMP00667Metipranolol Action Pathway
smpdbSMP00668Bevantolol Action Pathway
smpdbSMP00669Practolol Action Pathway
smpdbSMP00670Bupranolol Action Pathway
smpdbSMP00671Tramadol Action Action Pathway
smpdbSMP00672Propoxyphene Action Pathway
smpdbSMP00673Levorphanol Action Pathway
smpdbSMP00674Anileridine Action Pathway
smpdbSMP00675Diphenoxylate Action Pathway
smpdbSMP00676Dezocine Action Pathway
smpdbSMP00677Levomethadyl Acetate Action Action Pathway
smpdbSMP00678Methadyl Acetate Action Pathway
smpdbSMP006793-Methylthiofentanyl Action Pathway
smpdbSMP00680Dimethylthiambutene Action Pathway
smpdbSMP00681Ethylmorphine Action Pathway
smpdbSMP00683Levallorphan Action Pathway
smpdbSMP00684Buprenorphine Action Pathway
smpdbSMP00685Alvimopan Action Pathway
smpdbSMP00686Pentazocine Action Pathway
smpdbSMP00687Naltrexone Action Pathway
smpdbSMP00688Naloxone Action Pathway
smpdbSMP00689Dihydromorphine Action Pathway
smpdbSMP00690Ketobemidone Action Pathway
smpdbSMP00691Nalbuphine Action Pathway
smpdbSMP00723Cystinuria

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP1B1

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