ATP1B1
Summary: The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ATPase Na+/K+ transporting subunit beta 1 | MIM:182330 | Ensembl:ENSG00000143153 | HGNC:HGNC:804 | PA66 | 1q24.2 |
GO terms in ATP1B1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0001671 | ATPase activator activity |
| MF | IDA | GO:0001671 | ATPase activator activity |
| MF | IBA | GO:0005391 | sodium:potassium-exchanging ATPase activity |
| MF | IDA | GO:0005391 | sodium:potassium-exchanging ATPase activity |
| MF | ISS | GO:0005391 | sodium:potassium-exchanging ATPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008022 | protein C-terminus binding |
| MF | IPI | GO:0008144 | drug binding |
| MF | IDA | GO:0016887 | ATPase activity |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | HDA | GO:0023026 | MHC class II protein complex binding |
| MF | IDA | GO:0030955 | potassium ion binding |
| MF | IDA | GO:0031402 | sodium ion binding |
| MF | IPI | GO:0051117 | ATPase binding |
| CC | IEA | GO:0005622 | intracellular |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005890 | sodium:potassium-exchanging ATPase complex |
| CC | IDA | GO:0005890 | sodium:potassium-exchanging ATPase complex |
| CC | ISS | GO:0005890 | sodium:potassium-exchanging ATPase complex |
| CC | IEA | GO:0005901 | caveola |
| CC | ISS | GO:0014704 | intercalated disc |
| CC | IDA | GO:0016020 | membrane |
| CC | IEA | GO:0016323 | basolateral plasma membrane |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | ISS | GO:0042383 | sarcolemma |
| CC | IEA | GO:0043209 | myelin sheath |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | HDA | GO:1903561 | extracellular vesicle |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | ISS | GO:0006874 | cellular calcium ion homeostasis |
| BP | IBA | GO:0006883 | cellular sodium ion homeostasis |
| BP | IDA | GO:0006883 | cellular sodium ion homeostasis |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IBA | GO:0010107 | potassium ion import |
| BP | IDA | GO:0010107 | potassium ion import |
| BP | IEA | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient |
| BP | ISS | GO:0010468 | regulation of gene expression |
| BP | ISS | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling |
| BP | IBA | GO:0030007 | cellular potassium ion homeostasis |
| BP | IDA | GO:0030007 | cellular potassium ion homeostasis |
| BP | IDA | GO:0032781 | positive regulation of ATPase activity |
| BP | IBA | GO:0036376 | sodium ion export across plasma membrane |
| BP | IDA | GO:0036376 | sodium ion export across plasma membrane |
| BP | ISS | GO:0036376 | sodium ion export across plasma membrane |
| BP | TAS | GO:0044861 | protein transport into plasma membrane raft |
| BP | IDA | GO:0046034 | ATP metabolic process |
| BP | IDA | GO:0050821 | protein stabilization |
| BP | ISS | GO:0050821 | protein stabilization |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | ISS | GO:0055119 | relaxation of cardiac muscle |
| BP | ISS | GO:0060048 | cardiac muscle contraction |
| BP | IDA | GO:0072659 | protein localization to plasma membrane |
| BP | IDA | GO:0086009 | membrane repolarization |
| BP | IC | GO:0086013 | membrane repolarization during cardiac muscle cell action potential |
| BP | TAS | GO:0086064 | cell communication by electrical coupling involved in cardiac conduction |
| BP | IDA | GO:1901018 | positive regulation of potassium ion transmembrane transporter activity |
| BP | IDA | GO:1903278 | positive regulation of sodium ion export across plasma membrane |
| BP | ISS | GO:1903281 | positive regulation of calcium:sodium antiporter activity |
| BP | IDA | GO:1903288 | positive regulation of potassium ion import |
| BP | ISS | GO:1990573 | potassium ion import across plasma membrane |
Gene expression in normal tissue: ATP1B1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATP1B1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210991 | Basigin interactions |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5578775 | Ion homeostasis |
| reactome | R-HSA-936837 | Ion transport by P-type ATPases |
| reactome | R-HSA-983712 | Ion channel transport |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04260 | Cardiac muscle contraction - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| kegg | hsa04961 | Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) |
| kegg | hsa04964 | Proximal tubule bicarbonate reclamation - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| kegg | hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| kegg | hsa04973 | Carbohydrate digestion and absorption - Homo sapiens (human) |
| kegg | hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
| kegg | hsa04978 | Mineral absorption - Homo sapiens (human) |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| smpdb | SMP00078 | Chlorothiazide Action Pathway |
| smpdb | SMP00080 | Polythiazide Action Pathway |
| smpdb | SMP00081 | Methyclothiazide Action Pathway |
| smpdb | SMP00088 | Bumetanide Action Pathway |
| smpdb | SMP00090 | Bendroflumethiazide Action Pathway |
| smpdb | SMP00091 | Quinethazone Action Pathway |
| smpdb | SMP00097 | Ethacrynic Acid Action Pathway |
| smpdb | SMP00100 | Hydrochlorothiazide Action Pathway |
| smpdb | SMP00103 | Cyclothiazide Action Pathway |
| smpdb | SMP00105 | Metolazone Action Pathway |
| smpdb | SMP00108 | Hydroflumethiazide Action Pathway |
| smpdb | SMP00110 | Indapamide Action Pathway |
| smpdb | SMP00115 | Furosemide Action Pathway |
| smpdb | SMP00118 | Torsemide Action Pathway |
| smpdb | SMP00121 | Trichlormethiazide Action Pathway |
| smpdb | SMP00122 | Chlorthalidone Action Pathway |
| smpdb | SMP00132 | Triamterene Action Pathway |
| smpdb | SMP00133 | Amiloride Action Pathway |
| smpdb | SMP00134 | Spironolactone Action Pathway |
| smpdb | SMP00135 | Eplerenone Action Pathway |
| smpdb | SMP00184 | Glucose Transporter Defect (SGLT2) |
| smpdb | SMP00189 | Hartnup Disorder |
| smpdb | SMP00193 | Iminoglycinuria |
| smpdb | SMP00197 | Lysinuric Protein Intolerance |
| smpdb | SMP00245 | Glucose Transporter Defect (SGLT2) |
| smpdb | SMP00296 | Acebutolol Action Pathway |
| smpdb | SMP00297 | Alprenolol Action Pathway |
| smpdb | SMP00298 | Atenolol Action Pathway |
| smpdb | SMP00299 | Betaxolol Action Pathway |
| smpdb | SMP00300 | Bisoprolol Action Pathway |
| smpdb | SMP00301 | Esmolol Action Pathway |
| smpdb | SMP00302 | Metoprolol Action Pathway |
| smpdb | SMP00303 | Nadolol Action Pathway |
| smpdb | SMP00304 | Oxprenolol Action Pathway |
| smpdb | SMP00305 | Penbutolol Action Pathway |
| smpdb | SMP00306 | Pindolol Action Pathway |
| smpdb | SMP00307 | Propranolol Action Pathway |
| smpdb | SMP00323 | Quinidine Action Pathway |
| smpdb | SMP00324 | Procainamide (Antiarrhythmic) Action Pathway |
| smpdb | SMP00325 | Disopyramide Action Pathway |
| smpdb | SMP00326 | Fosphenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00328 | Lidocaine (Antiarrhythmic) Action Pathway |
| smpdb | SMP00329 | Mexiletine Action Pathway |
| smpdb | SMP00330 | Tocainide Action Pathway |
| smpdb | SMP00331 | Flecainide Action Pathway |
| smpdb | SMP00332 | Ibutilide Action Pathway |
| smpdb | SMP00359 | Diltiazem Action Pathway |
| smpdb | SMP00366 | Nebivolol Action Pathway |
| smpdb | SMP00367 | Carvedilol Action Pathway |
| smpdb | SMP00368 | Labetalol Action Pathway |
| smpdb | SMP00375 | Verapamil Action Pathway |
| smpdb | SMP00376 | Amlodipine Action Pathway |
| smpdb | SMP00377 | Felodipine Action Pathway |
| smpdb | SMP00378 | Isradipine Action Pathway |
| smpdb | SMP00379 | Nifedipine Action Pathway |
| smpdb | SMP00380 | Nimodipine Action Pathway |
| smpdb | SMP00381 | Nisoldipine Action Pathway |
| smpdb | SMP00382 | Nitrendipine Action Pathway |
| smpdb | SMP00392 | Benzocaine Action Pathway |
| smpdb | SMP00393 | Bupivacaine Action Pathway |
| smpdb | SMP00394 | Chloroprocaine Action Pathway |
| smpdb | SMP00395 | Cocaine Action Pathway |
| smpdb | SMP00396 | Dibucaine Action Pathway |
| smpdb | SMP00397 | Levobupivacaine Action Pathway |
| smpdb | SMP00398 | Lidocaine (Local Anaesthetic) Action Pathway |
| smpdb | SMP00399 | Mepivacaine Action Pathway |
| smpdb | SMP00400 | Oxybuprocaine Action Pathway |
| smpdb | SMP00401 | Prilocaine Action Pathway |
| smpdb | SMP00402 | Procaine Action Pathway |
| smpdb | SMP00403 | Proparacaine Action Pathway |
| smpdb | SMP00404 | Ropivacaine Action Pathway |
| smpdb | SMP00405 | Codeine Action Pathway |
| smpdb | SMP00406 | Morphine Action Pathway |
| smpdb | SMP00407 | Heroin Action Pathway |
| smpdb | SMP00408 | Methadone Action Pathway |
| smpdb | SMP00409 | Oxycodone Action Pathway |
| smpdb | SMP00410 | Hydromorphone Action Pathway |
| smpdb | SMP00411 | Hydrocodone Action Pathway |
| smpdb | SMP00412 | Oxymorphone Action Pathway |
| smpdb | SMP00413 | Alfentanil Action Pathway |
| smpdb | SMP00414 | Carfentanil Action Pathway |
| smpdb | SMP00415 | Fentanyl Action Pathway |
| smpdb | SMP00416 | Remifentanil Action Pathway |
| smpdb | SMP00417 | Sufentanil Action Pathway |
| smpdb | SMP00422 | Imipramine Action Pathway |
| smpdb | SMP00423 | Desipramine Action Pathway |
| smpdb | SMP00424 | Citalopram Action Pathway |
| smpdb | SMP00425 | Escitalopram Action Pathway |
| smpdb | SMP00426 | Fluoxetine Action Pathway |
| smpdb | SMP00431 | Nicotine Action Pathway |
| smpdb | SMP00457 | Lactose Degradation |
| smpdb | SMP00458 | Lactose Intolerance |
| smpdb | SMP00467 | Trehalose Degradation |
| smpdb | SMP00483 | Kidney Function |
| smpdb | SMP00583 | Blue diaper syndrome |
| smpdb | SMP00585 | Lysinuric protein intolerance (LPI) |
| smpdb | SMP00588 | Muscle/Heart Contraction |
| smpdb | SMP00657 | Bopindolol Action Pathway |
| smpdb | SMP00658 | Carteolol Action Pathway |
| smpdb | SMP00659 | Timolol Action Pathway |
| smpdb | SMP00660 | Sotalol Action Pathway |
| smpdb | SMP00661 | Epinephrine Action Pathway |
| smpdb | SMP00662 | Dobutamine Action Pathway |
| smpdb | SMP00663 | Isoprenaline Action Pathway |
| smpdb | SMP00664 | Arbutamine Action Pathway |
| smpdb | SMP00665 | Amiodarone Action Pathway |
| smpdb | SMP00666 | Levobunolol Action Pathway |
| smpdb | SMP00667 | Metipranolol Action Pathway |
| smpdb | SMP00668 | Bevantolol Action Pathway |
| smpdb | SMP00669 | Practolol Action Pathway |
| smpdb | SMP00670 | Bupranolol Action Pathway |
| smpdb | SMP00671 | Tramadol Action Action Pathway |
| smpdb | SMP00672 | Propoxyphene Action Pathway |
| smpdb | SMP00673 | Levorphanol Action Pathway |
| smpdb | SMP00674 | Anileridine Action Pathway |
| smpdb | SMP00675 | Diphenoxylate Action Pathway |
| smpdb | SMP00676 | Dezocine Action Pathway |
| smpdb | SMP00677 | Levomethadyl Acetate Action Action Pathway |
| smpdb | SMP00678 | Methadyl Acetate Action Pathway |
| smpdb | SMP00679 | 3-Methylthiofentanyl Action Pathway |
| smpdb | SMP00680 | Dimethylthiambutene Action Pathway |
| smpdb | SMP00681 | Ethylmorphine Action Pathway |
| smpdb | SMP00683 | Levallorphan Action Pathway |
| smpdb | SMP00684 | Buprenorphine Action Pathway |
| smpdb | SMP00685 | Alvimopan Action Pathway |
| smpdb | SMP00686 | Pentazocine Action Pathway |
| smpdb | SMP00687 | Naltrexone Action Pathway |
| smpdb | SMP00688 | Naloxone Action Pathway |
| smpdb | SMP00689 | Dihydromorphine Action Pathway |
| smpdb | SMP00690 | Ketobemidone Action Pathway |
| smpdb | SMP00691 | Nalbuphine Action Pathway |
| smpdb | SMP00723 | Cystinuria |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATP1B1
CLASSFICATION
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