ATP2B4
Summary: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ATPase plasma membrane Ca2+ transporting 4 | MIM:108732 | Ensembl:ENSG00000058668 | HGNC:HGNC:817 | PA25110 | 1q32.1 |
GO terms in ATP2B4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0003407 | neural retina development |
| BP | IMP | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0006874 | cellular calcium ion homeostasis |
| BP | IC | GO:0006874 | cellular calcium ion homeostasis |
| BP | IDA | GO:0006874 | cellular calcium ion homeostasis |
| BP | ISS | GO:0006874 | cellular calcium ion homeostasis |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IDA | GO:0010751 | negative regulation of nitric oxide mediated signal transduction |
| BP | IEA | GO:0021766 | hippocampus development |
| BP | ISS | GO:0030317 | flagellated sperm motility |
| BP | IDA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | TAS | GO:0034220 | ion transmembrane transport |
| BP | IDA | GO:0045019 | negative regulation of nitric oxide biosynthetic process |
| BP | IDA | GO:0051001 | negative regulation of nitric-oxide synthase activity |
| BP | IBA | GO:0051480 | regulation of cytosolic calcium ion concentration |
| BP | IMP | GO:0051599 | response to hydrostatic pressure |
| BP | IMP | GO:0070588 | calcium ion transmembrane transport |
| BP | IDA | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade |
| BP | IDA | GO:0071872 | cellular response to epinephrine stimulus |
| BP | IC | GO:0097553 | calcium ion transmembrane import into cytosol |
| BP | IC | GO:0098703 | calcium ion import across plasma membrane |
| BP | IDA | GO:0098736 | negative regulation of the force of heart contraction |
| BP | IEA | GO:0099132 | ATP hydrolysis coupled cation transmembrane transport |
| BP | IDA | GO:0140199 | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process |
| BP | IDA | GO:1900082 | negative regulation of arginine catabolic process |
| BP | IEA | GO:1901660 | calcium ion export |
| BP | NAS | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation |
| BP | IC | GO:1902305 | regulation of sodium ion transmembrane transport |
| BP | IMP | GO:1902806 | regulation of cell cycle G1/S phase transition |
| BP | IMP | GO:1903243 | negative regulation of cardiac muscle hypertrophy in response to stress |
| BP | IDA | GO:1903249 | negative regulation of citrulline biosynthetic process |
| BP | TAS | GO:1903779 | regulation of cardiac conduction |
| BP | IDA | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005901 | caveola |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IEA | GO:0016323 | basolateral plasma membrane |
| CC | IDA | GO:0030018 | Z disc |
| CC | IDA | GO:0030315 | T-tubule |
| CC | ISS | GO:0032991 | protein-containing complex |
| CC | ISS | GO:0036126 | sperm flagellum |
| CC | IEA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IEA | GO:0097228 | sperm principal piece |
| MF | IBA | GO:0005388 | calcium-transporting ATPase activity |
| MF | IMP | GO:0005388 | calcium-transporting ATPase activity |
| MF | TAS | GO:0005388 | calcium-transporting ATPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | ISS | GO:0017080 | sodium channel regulator activity |
| MF | IBA | GO:0019829 | cation-transporting ATPase activity |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0030165 | PDZ domain binding |
| MF | IDA | GO:0030346 | protein phosphatase 2B binding |
| MF | IDA | GO:0036487 | nitric-oxide synthase inhibitor activity |
| MF | IDA | GO:0036487 | nitric-oxide synthase inhibitor activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IPI | GO:0050998 | nitric-oxide synthase binding |
| MF | ISS | GO:0097110 | scaffold protein binding |
Gene expression in normal tissue: ATP2B4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATP2B4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418359 | Reduction of cytosolic Ca++ levels |
| reactome | R-HSA-418360 | Platelet calcium homeostasis |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5578775 | Ion homeostasis |
| reactome | R-HSA-936837 | Ion transport by P-type ATPases |
| reactome | R-HSA-983712 | Ion channel transport |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| kegg | hsa04972 | Pancreatic secretion - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATP2B4
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