Summary: The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

ATPase phospholipid transporting 8A1MIM:609542Ensembl:ENSG00000124406HGNC:HGNC:13531PA251654p13

GO terms in ATP8A1

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000287magnesium ion binding
MFIBAGO:0004012phospholipid-translocating ATPase activity
MFTASGO:0004012phospholipid-translocating ATPase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFNASGO:0019829cation-transporting ATPase activity
BPIEAGO:0030335positive regulation of cell migration
BPTASGO:0034220ion transmembrane transport
BPTASGO:0043312neutrophil degranulation
BPIBAGO:0045332phospholipid translocation
BPNASGO:0045332phospholipid translocation
BPIBAGO:0048194Golgi vesicle budding
BPIEAGO:0061092positive regulation of phospholipid translocation
BPIEAGO:0099132ATP hydrolysis coupled cation transmembrane transport
CCIEAGO:0000139Golgi membrane
CCIDAGO:0005783endoplasmic reticulum
CCIBAGO:0005794Golgi apparatus
CCIDAGO:0005794Golgi apparatus
CCIBAGO:0005802trans-Golgi network
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCTASGO:0035577azurophil granule membrane
CCTASGO:0035579specific granule membrane
CCIEAGO:0042584chromaffin granule membrane
CCIDAGO:0043231intracellular membrane-bounded organelle
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: ATP8A1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATP8A1

DatabasePathway IDPathway Des.
wikipathwaysWP24Peptide GPCRs
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-936837Ion transport by P-type ATPases
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP8A1