ATP8A1
Summary: The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ATPase phospholipid transporting 8A1 | MIM:609542 | Ensembl:ENSG00000124406 | HGNC:HGNC:13531 | PA25165 | 4p13 |
GO terms in ATP8A1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004012 | phospholipid-translocating ATPase activity |
| MF | TAS | GO:0004012 | phospholipid-translocating ATPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | NAS | GO:0019829 | cation-transporting ATPase activity |
| BP | IEA | GO:0007612 | learning |
| BP | IEA | GO:0030335 | positive regulation of cell migration |
| BP | TAS | GO:0034220 | ion transmembrane transport |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IBA | GO:0045332 | phospholipid translocation |
| BP | NAS | GO:0045332 | phospholipid translocation |
| BP | IBA | GO:0048194 | Golgi vesicle budding |
| BP | IEA | GO:0061092 | positive regulation of phospholipid translocation |
| BP | IEA | GO:0099132 | ATP hydrolysis coupled cation transmembrane transport |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0005802 | trans-Golgi network |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0035577 | azurophil granule membrane |
| CC | TAS | GO:0035579 | specific granule membrane |
| CC | IEA | GO:0042584 | chromaffin granule membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: ATP8A1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATP8A1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP24 | Peptide GPCRs |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-936837 | Ion transport by P-type ATPases |
| reactome | R-HSA-983712 | Ion channel transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATP8A1
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