ATP8A1


Summary: The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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GO terms in ATP8A1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0000287 magnesium ion binding
MF IBA GO:0004012 phospholipid-translocating ATPase activity
MF TAS GO:0004012 phospholipid-translocating ATPase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF NAS GO:0019829 cation-transporting ATPase activity
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Gene expression in normal tissue: ATP8A1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATP8A1


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Database
Pathway ID
Pathway Des.
wikipathways WP24 Peptide GPCRs
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-382551 Transport of small molecules
reactome R-HSA-6798695 Neutrophil degranulation
reactome R-HSA-936837 Ion transport by P-type ATPases
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP8A1

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Level
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Cancer
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