ATP8B1


Summary: This gene encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ATPase phospholipid transporting 8B1MIM:602397Ensembl:ENSG00000081923HGNC:HGNC:3706PA26518q21.31

GO terms in ATP8B1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000287magnesium ion binding
MFIBAGO:0004012phospholipid-translocating ATPase activity
MFTASGO:0004012phospholipid-translocating ATPase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0015247aminophospholipid transmembrane transporter activity
MFIEAGO:1901612cardiolipin binding
BPIDAGO:0006855drug transmembrane transport
BPIBAGO:0007030Golgi organization
BPIEAGO:0007605sensory perception of sound
BPIEAGO:0008206bile acid metabolic process
BPNASGO:0015721bile acid and bile salt transport
BPIEAGO:0015917aminophospholipid transport
BPIEAGO:0021650vestibulocochlear nerve formation
BPIMPGO:0032534regulation of microvillus assembly
BPTASGO:0034220ion transmembrane transport
BPIBAGO:0045332phospholipid translocation
BPIDAGO:0045332phospholipid translocation
BPNASGO:0045332phospholipid translocation
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIEAGO:0060119inner ear receptor cell development
CCIDAGO:0005783endoplasmic reticulum
CCIBAGO:0005794Golgi apparatus
CCIDAGO:0005794Golgi apparatus
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCNASGO:0005887integral component of plasma membrane
CCIDAGO:0016324apical plasma membrane
CCIEAGO:0031526brush border membrane
CCIEAGO:0032420stereocilium

Gene expression in normal tissue: ATP8B1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATP8B1


DatabasePathway IDPathway Des.
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-936837Ion transport by P-type ATPases
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD546BMS-7548071
iGMDRD670ML 2102
iGMDRD781Sirolimus2
iGMDRD494Neopeltolide3
iGMDRD126Tipifarnib2
iGMDRD599Salermide3
iGMDRD634SCHEMBL26080412
iGMDRD107Valdecoxib2
iGMDRD201SKI II2
iGMDRD71Sparfosic acid3
iGMDRD193Fqi12
iGMDRD782DC-45-A22
iGMDRD441TW 371
iGMDRD318PAC-13
iGMDRD226ML0062
iGMDRD260FQI-22
iGMDRD131Erlotinib1
iGMDRD64Parbendazole3
iGMDRD268Cerulenin1
iGMDRD23Gossypol2
iGMDRD399Selumetinib3
iGMDRD74Idarubicin2
iGMDRD887Compound 23 citrate3
iGMDRD577BIX012943
iGMDRD116CD4372
iGMDRD652UNC06383
iGMDRD405PIK-752
iGMDRD84Lovastatin acid1
iGMDRD248BRD43541
iGMDRD512nutlin 32
iGMDRD123Isoevodiamine4
iGMDRD211(1S,3R)-RSL32
iGMDRD351GW843682X2
iGMDRD434BMS-5369243
iGMDRD481Dactolisib2
iGMDRD158NSC1415404
iGMDRD271Brefeldin A2
iGMDRD103SN-384
iGMDRD5Tyrphostin AG 14783
iGMDRD246NPC262
iGMDRD300Tozasertib2
iGMDRD366PI-1032
iGMDRD329Merck602

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP8B1

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