AURKC


Summary: This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
aurora kinase CMIM:603495Ensembl:ENSG00000105146HGNC:HGNC:11391PA3620019q13.43

GO terms in AURKC


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0000780condensed nuclear chromosome, centromeric region
CCIDAGO:0000793condensed chromosome
CCIEAGO:0005737cytoplasm
CCTASGO:0005819spindle
CCIBAGO:0005876spindle microtubule
CCIDAGO:0030496midbody
CCTASGO:0030496midbody
CCIBAGO:0031616spindle pole centrosome
CCIBAGO:0032133chromosome passenger complex
CCTASGO:0032133chromosome passenger complex
CCIBAGO:0051233spindle midzone
CCIDAGO:0051233spindle midzone
BPIEAGO:0000910cytokinesis
BPIDAGO:0006468protein phosphorylation
BPIBAGO:0007052mitotic spindle organization
BPIEAGO:0007283spermatogenesis
BPTASGO:0008608attachment of spindle microtubules to kinetochore
BPTASGO:0016570histone modification
BPIBAGO:0032465regulation of cytokinesis
BPTASGO:0032467positive regulation of cytokinesis
BPIEAGO:0035404histone-serine phosphorylation
BPIEAGO:0048599oocyte development
BPTASGO:0051256mitotic spindle midzone assembly
BPIEAGO:0051321meiotic cell cycle
MFIDAGO:0004672protein kinase activity
MFTASGO:0004712protein serine/threonine/tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0035174histone serine kinase activity

Gene expression in normal tissue: AURKC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AURKC


DatabasePathway IDPathway Des.
pidaurora_b_pathwayAurora B signaling
pidaurora_c_pathwayAurora C signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib3
iGMDRD414MST-3129
iGMDRD286Nsc 6328396
iGMDRD351GW843682X3
iGMDRD329Merck603
iGMDRD60Quinoclamine3
iGMDRD270Ciclosporin3
iGMDRD387CHIR-990213
iGMDRD705Nakiterpiosin9
iGMDRD484Pluripotin6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AURKC

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