B3GNT4
Summary: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase protein family. The encoded enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and prefers lacto-N-neotetraose as a substrate. It is a type II transmembrane protein. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 | MIM:605864 | Ensembl:ENSG00000176383 | HGNC:HGNC:15683 | PA25220 | 12q24.31 |
GO terms in B3GNT4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0008375 | acetylglucosaminyltransferase activity |
| MF | IBA | GO:0008376 | acetylgalactosaminyltransferase activity |
| MF | TAS | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity |
| MF | IBA | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity |
| MF | IDA | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity |
| MF | TAS | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity |
| MF | IBA | GO:0016758 | transferase activity, transferring hexosyl groups |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IBA | GO:0006486 | protein glycosylation |
| BP | IBA | GO:0006493 | protein O-linked glycosylation |
| BP | TAS | GO:0016266 | O-glycan processing |
| BP | TAS | GO:0018146 | keratan sulfate biosynthetic process |
| BP | IBA | GO:0030311 | poly-N-acetyllactosamine biosynthetic process |
| BP | IDA | GO:0030311 | poly-N-acetyllactosamine biosynthetic process |
Gene expression in normal tissue: B3GNT4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in B3GNT4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
| reactome | R-HSA-1638074 | Keratan sulfate/keratin metabolism |
| reactome | R-HSA-2022854 | Keratan sulfate biosynthesis |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5173105 | O-linked glycosylation |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-913709 | O-linked glycosylation of mucins |
| kegg | hsa00601 | Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in B3GNT4
CLASSFICATION
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