BAG3
Summary: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BCL2 associated athanogene 3 | MIM:603883 | Ensembl:ENSG00000151929 | HGNC:HGNC:939 | PA25239 | 10q26.11 |
GO terms in BAG3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000774 | adenyl-nucleotide exchange factor activity |
| MF | TAS | GO:0000774 | adenyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0051087 | chaperone binding |
| BP | NAS | GO:0006457 | protein folding |
| BP | IEA | GO:0007420 | brain development |
| BP | IDA | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IEA | GO:0010664 | negative regulation of striated muscle cell apoptotic process |
| BP | IEA | GO:0021510 | spinal cord development |
| BP | IDA | GO:0034605 | cellular response to heat |
| BP | IMP | GO:0042307 | positive regulation of protein import into nucleus |
| BP | NAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0046827 | positive regulation of protein export from nucleus |
| BP | IEA | GO:0050790 | regulation of catalytic activity |
| BP | IEA | GO:0050821 | protein stabilization |
| BP | IEA | GO:0071260 | cellular response to mechanical stimulus |
| BP | IEA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IMP | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| BP | IEA | GO:1903215 | negative regulation of protein targeting to mitochondrion |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0030018 | Z disc |
| CC | IEA | GO:0043005 | neuron projection |
Gene expression in normal tissue: BAG3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BAG3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165374494 | Busulfan Pathway, Pharmacodynamics |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BAG3
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