Summary: The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009].

BAI1 associated protein 2MIM:605475Ensembl:ENSG00000175866HGNC:HGNC:947PA2525117q25.3

GO terms in BAIAP2

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0007009plasma membrane organization
BPIEAGO:0007420brain development
BPTASGO:0008286insulin receptor signaling pathway
BPISSGO:0008360regulation of cell shape
BPIMPGO:0009617response to bacterium
BPIEAGO:0016358dendrite development
BPIBAGO:0030838positive regulation of actin filament polymerization
BPIMPGO:0032956regulation of actin cytoskeleton organization
BPIEAGO:0035418protein localization to synapse
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIEAGO:0048167regulation of synaptic plasticity
BPIBAGO:0051017actin filament bundle assembly
BPISSGO:0051017actin filament bundle assembly
BPIBAGO:0051764actin crosslink formation
BPISSGO:0051764actin crosslink formation
BPIEAGO:0061003positive regulation of dendritic spine morphogenesis
BPIEAGO:0071364cellular response to epidermal growth factor stimulus
BPIEAGO:0098609cell-cell adhesion
BPIEAGO:1905232cellular response to L-glutamate
BPIBAGO:2000251positive regulation of actin cytoskeleton reorganization
BPIEAGO:2000463positive regulation of excitatory postsynaptic potential
CCIEAGO:0005791rough endoplasmic reticulum
CCIEAGO:0005794Golgi apparatus
CCIDAGO:0005886plasma membrane
CCHDAGO:0005913cell-cell adherens junction
CCIEAGO:0014069postsynaptic density
CCIBAGO:0015629actin cytoskeleton
CCIDAGO:0015629actin cytoskeleton
CCIEAGO:0030141secretory granule
CCIEAGO:0043025neuronal cell body
CCIEAGO:0043198dendritic shaft
CCIEAGO:0044306neuron projection terminus
CCIEAGO:0060076excitatory synapse
CCIEAGO:0061845neuron projection branch point
CCIEAGO:0061846dendritic spine cytoplasm
CCHDAGO:0070062extracellular exosome
CCIEAGO:0097060synaptic membrane
MFIEAGO:0001221transcription cofactor binding
MFIPIGO:0005515protein binding
MFTASGO:0008022protein C-terminus binding
MFIEAGO:0008093cytoskeletal adaptor activity
MFIEAGO:0030165PDZ domain binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0070064proline-rich region binding
MFIEAGO:0097110scaffold protein binding
MFHDAGO:0098641cadherin binding involved in cell-cell adhesion

Gene expression in normal tissue: BAIAP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BAIAP2

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029482Regulation of actin dynamics for phagocytic cup formation
reactomeR-HSA-2029482Regulation of actin dynamics for phagocytic cup formation
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-5663213RHO GTPases Activate WASPs and WAVEs
reactomeR-HSA-5663213RHO GTPases Activate WASPs and WAVEs
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP51Regulation of Actin Cytoskeleton
pidcdc42_pathwayCDC42 signaling events
piderbb1_downstream_pathwayErbB1 downstream signaling
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidrac1_pathwayRAC1 signaling pathway
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BAIAP2