BAIAP2L1
Summary: This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BAI1 associated protein 2 like 1 | MIM:611877 | Ensembl:ENSG00000006453 | HGNC:HGNC:21649 | PA142672562 | 7q21.3-q22.1 |
GO terms in BAIAP2L1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005913 | cell-cell adherens junction |
| CC | IBA | GO:0015629 | actin cytoskeleton |
| CC | IDA | GO:0015629 | actin cytoskeleton |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0007009 | plasma membrane organization |
| BP | IDA | GO:0009617 | response to bacterium |
| BP | IBA | GO:0030838 | positive regulation of actin filament polymerization |
| BP | IDA | GO:0030838 | positive regulation of actin filament polymerization |
| BP | IEA | GO:0046626 | regulation of insulin receptor signaling pathway |
| BP | IBA | GO:0051017 | actin filament bundle assembly |
| BP | IBA | GO:0051764 | actin crosslink formation |
| BP | IEA | GO:0098609 | cell-cell adhesion |
| BP | IBA | GO:2000251 | positive regulation of actin cytoskeleton reorganization |
| BP | IMP | GO:2000251 | positive regulation of actin cytoskeleton reorganization |
| MF | IEA | GO:0003779 | actin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0070064 | proline-rich region binding |
| MF | HDA | GO:0098641 | cadherin binding involved in cell-cell adhesion |
Gene expression in normal tissue: BAIAP2L1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BAIAP2L1
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