Summary: This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008].

bromodomain adjacent to zinc finger domain 1BMIM:605681Ensembl:ENSG00000009954HGNC:HGNC:961PA252717q11.23

GO terms in BAZ1B

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006333chromatin assembly or disassembly
BPTASGO:0006338chromatin remodeling
BPIEAGO:0006351transcription, DNA-templated
BPNASGO:0006357regulation of transcription by RNA polymerase II
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0016572histone phosphorylation
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPTASGO:0045815positive regulation of gene expression, epigenetic
CCIEAGO:0000793condensed chromosome
CCIEAGO:0005721pericentric heterochromatin
CCIDAGO:0016604nuclear body
CCIDAGO:0043596nuclear replication fork
MFIDAGO:0004713protein tyrosine kinase activity
MFIEAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFNASGO:0008270zinc ion binding
MFIDAGO:0035173histone kinase activity
MFIEAGO:0042393histone binding

Gene expression in normal tissue: BAZ1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BAZ1B

DatabasePathway IDPathway Des.
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-5250913Positive epigenetic regulation of rRNA expression
reactomeR-HSA-5250924B-WICH complex positively regulates rRNA expression
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
reactomeR-HSA-5693606DNA Double Strand Break Response
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BAZ1B