BCCIP
Summary: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BRCA2 and CDKN1A interacting protein | MIM:611883 | Ensembl:ENSG00000107949 | HGNC:HGNC:978 | PA25290 | 10q26.2 |
GO terms in BCCIP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0015631 | tubulin binding |
| MF | IBA | GO:0019207 | kinase regulator activity |
| MF | IDA | GO:0019207 | kinase regulator activity |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | IBA | GO:0005814 | centriole |
| CC | IDA | GO:0005814 | centriole |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex |
| CC | IDA | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex |
| CC | IBA | GO:0097431 | mitotic spindle pole |
| CC | IDA | GO:0097431 | mitotic spindle pole |
| BP | IBA | GO:0000055 | ribosomal large subunit export from nucleus |
| BP | IBA | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IDA | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IBA | GO:0000132 | establishment of mitotic spindle orientation |
| BP | IMP | GO:0000226 | microtubule cytoskeleton organization |
| BP | IEA | GO:0006281 | DNA repair |
| BP | IBA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IBA | GO:0007052 | mitotic spindle organization |
| BP | IMP | GO:0007052 | mitotic spindle organization |
| BP | IBA | GO:0034453 | microtubule anchoring |
| BP | IMP | GO:0034453 | microtubule anchoring |
| BP | IDA | GO:0061101 | neuroendocrine cell differentiation |
| BP | IBA | GO:0090307 | mitotic spindle assembly |
| BP | IMP | GO:0090307 | mitotic spindle assembly |
Gene expression in normal tissue: BCCIP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCCIP
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCCIP
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