BIRC7
Summary: This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| baculoviral IAP repeat containing 7 | MIM:605737 | Ensembl:ENSG00000101197 | HGNC:HGNC:13702 | PA25364 | 20q13.33 |
GO terms in BIRC7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | TAS | GO:0004869 | cysteine-type endopeptidase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0019899 | enzyme binding |
| MF | IBA | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | NAS | GO:0007257 | activation of JUN kinase activity |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0042127 | regulation of cell proliferation |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | NAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0070247 | regulation of natural killer cell apoptotic process |
| BP | IBA | GO:0090307 | mitotic spindle assembly |
| BP | IBA | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: BIRC7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BIRC7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP4241 | Type 2 papillary renal cell carcinoma |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BIRC7
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