BMX


Summary: This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
BMX non-receptor tyrosine kinaseMIM:300101Ensembl:ENSG00000102010HGNC:HGNC:1079PA25389Xp22.2

GO terms in BMX


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0002250adaptive immune response
BPTASGO:0006468protein phosphorylation
BPTASGO:0006661phosphatidylinositol biosynthetic process
BPIEAGO:0006915apoptotic process
BPIEAGO:0007155cell adhesion
BPIDAGO:0007165signal transduction
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPTASGO:0007498mesoderm development
BPIBAGO:0030154cell differentiation
BPIEAGO:0035556intracellular signal transduction
BPIBAGO:0038083peptidyl-tyrosine autophosphorylation
BPIBAGO:0042127regulation of cell proliferation
BPIBAGO:0045087innate immune response
BPIDAGO:0046777protein autophosphorylation
BPIBAGO:0050852T cell receptor signaling pathway
BPIBAGO:0050853B cell receptor signaling pathway
CCIDAGO:0005654nucleoplasm
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIBAGO:0031234extrinsic component of cytoplasmic side of plasma membrane
CCIDAGO:0032587ruffle membrane
MFTASGO:0004713protein tyrosine kinase activity
MFIBAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIDAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFTASGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIBAGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: BMX

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BMX


DatabasePathway IDPathway Des.
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-111465Apoptotic cleavage of cellular proteins
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483255PI Metabolism
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-1660499Synthesis of PIPs at the plasma membrane
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-75153Apoptotic execution phase
netpathPathway_IL6IL6
pidangiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
pidfak_pathwaySignaling events mediated by focal adhesion kinase
wikipathwaysWP1993Angiogenesis overview

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD188Piperlongumine3
iGMDRD513BML-2593
iGMDRD100Zebularine3
iGMDRD679Bistramide A1
iGMDRD187BRD98763

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BMX

​​​​