BOC


Summary: The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
BOC cell adhesion associated, oncogene regulatedMIM:608708Ensembl:ENSG00000144857HGNC:HGNC:17173PA1434853163q13.2

Gene Categories:

DRUGGABLE GENOME

GO terms in BOC


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
CCIDAGO:0005654nucleoplasm
CCTASGO:0005886plasma membrane
CCIEAGO:0005887integral component of plasma membrane
CCIEAGO:0044295axonal growth cone
BPIEAGO:0007155cell adhesion
BPIEAGO:0007224smoothened signaling pathway
BPIEAGO:0007411axon guidance
BPISSGO:0045663positive regulation of myoblast differentiation
BPTASGO:0051149positive regulation of muscle cell differentiation

Gene expression in normal tissue: BOC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BOC


DatabasePathway IDPathway Des.
kegghsa04340Hedgehog signaling pathway - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
pidhedgehog_2pathwaySignaling events mediated by the Hedgehog family
wikipathwaysWP2858Ectoderm Differentiation
wikipathwaysWP3313Hedgehog ,on, state
wikipathwaysWP4249Hedgehog Signaling Pathway
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-375170CDO in myogenesis
reactomeR-HSA-375170CDO in myogenesis
reactomeR-HSA-525793Myogenesis
reactomeR-HSA-525793Myogenesis
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5632681Ligand-receptor interactions
reactomeR-HSA-5632684Hedgehog 'on' state
reactomeR-HSA-5632684Hedgehog 'on' state
reactomeR-HSA-5635838Activation of SMO

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD748PHA-6657521
iGMDRD30917AAG1
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BOC

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