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BPI

Summary: This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
bactericidal permeability increasing protein	MIM:109195	Ensembl:ENSG00000101425	HGNC:HGNC:1095	PA25403	20q11.23

Gene Categories:

DRUGGABLE GENOME

GO terms in BPI

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0001530	lipopolysaccharide binding
BP	TAS	GO:0019730	antimicrobial humoral response
BP	IDA	GO:0032715	negative regulation of interleukin-6 production
BP	IDA	GO:0032717	negative regulation of interleukin-8 production
BP	IDA	GO:0032720	negative regulation of tumor necrosis factor production
BP	IDA	GO:0043031	negative regulation of macrophage activation
BP	TAS	GO:0043312	neutrophil degranulation
BP	IEA	GO:0050829	defense response to Gram-negative bacterium
CC	TAS	GO:0005576	extracellular region
CC	IEA	GO:0016020	membrane
CC	TAS	GO:0035578	azurophil granule lumen
CC	TAS	GO:0035580	specific granule lumen
CC	HDA	GO:0070062	extracellular exosome

Gene expression in normal tissue: BPI

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BPI

Database	Pathway ID	Pathway Des.
reactome	R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168898	Toll-Like Receptors Cascades
reactome	R-HSA-6798695	Neutrophil degranulation
reactome	R-HSA-6803157	Antimicrobial peptides

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BPI

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DATATYPES

CLASSFICATION

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