BRD2
Summary: This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| bromodomain containing 2 | MIM:601540 | Ensembl:ENSG00000204256 | HGNC:HGNC:1103 | PA25414 | 6p21.32 |
GO terms in BRD2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0016607 | nuclear speck |
| BP | IMP | GO:0006334 | nucleosome assembly |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0007283 | spermatogenesis |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0070577 | lysine-acetylated histone binding |
Gene expression in normal tissue: BRD2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BRD2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3295 | Chemical Compounds to monitor Proteins |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8951936 | RUNX3 regulates p14-ARF |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD314 | Tanespimycin | 5 |
| iGMDRD701 | NVP-AUY922 | 6 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD554 | CHEMBL1434137 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BRD2
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