BRDT
Summary: BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| bromodomain testis associated | MIM:602144 | Ensembl:ENSG00000137948 | HGNC:HGNC:1105 | PA25418 | 1p22.1 |
GO terms in BRDT
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0042393 | histone binding |
| MF | ISS | GO:0070577 | lysine-acetylated histone binding |
| BP | ISS | GO:0001207 | histone displacement |
| BP | ISS | GO:0006338 | chromatin remodeling |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IMP | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | ISS | GO:0007140 | male meiotic nuclear division |
| BP | ISS | GO:0007141 | male meiosis I |
| BP | ISS | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0008380 | RNA splicing |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | ISS | GO:0043484 | regulation of RNA splicing |
| BP | ISS | GO:0051039 | positive regulation of transcription involved in meiotic cell cycle |
| CC | ISS | GO:0005634 | nucleus |
Gene expression in normal tissue: BRDT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BRDT
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3295 | Chemical Compounds to monitor Proteins |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD499 | PDMP | 4 |
| iGMDRD341 | Triacsin c | 4 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD221 | Tamoxifen | 6 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD484 | Pluripotin | 4 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD579 | PF750 | 5 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD506 | Fedratinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BRDT
CLASSFICATION
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