ZFP36L2
Summary: This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ZFP36 ring finger protein like 2 | MIM:612053 | Ensembl:ENSG00000152518 | HGNC:HGNC:1108 | PA35028 | 2p21 |
Gene Categories:
TUMOR SUPPRESSORGO terms in ZFP36L2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003730 | mRNA 3'-UTR binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0017091 | AU-rich element binding |
| MF | IDA | GO:0035925 | mRNA 3'-UTR AU-rich region binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | ISS | GO:0005634 | nucleus |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| BP | IEA | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0006402 | mRNA catabolic process |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IDA | GO:0009611 | response to wounding |
| BP | ISS | GO:0030097 | hemopoiesis |
| BP | ISS | GO:0033077 | T cell differentiation in thymus |
| BP | ISS | GO:0035019 | somatic stem cell population maintenance |
| BP | IMP | GO:0043488 | regulation of mRNA stability |
| BP | ISS | GO:0043488 | regulation of mRNA stability |
| BP | IDA | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| BP | ISS | GO:0045577 | regulation of B cell differentiation |
| BP | ISS | GO:0045599 | negative regulation of fat cell differentiation |
| BP | ISS | GO:0048103 | somatic stem cell division |
| BP | ISS | GO:0060216 | definitive hemopoiesis |
| BP | IBA | GO:0061158 | 3'-UTR-mediated mRNA destabilization |
| BP | IMP | GO:0061158 | 3'-UTR-mediated mRNA destabilization |
| BP | ISS | GO:0061158 | 3'-UTR-mediated mRNA destabilization |
| BP | IDA | GO:0070371 | ERK1 and ERK2 cascade |
| BP | IDA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IDA | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IDA | GO:0071385 | cellular response to glucocorticoid stimulus |
| BP | IDA | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| BP | IDA | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus |
| BP | ISS | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| BP | ISS | GO:1901991 | negative regulation of mitotic cell cycle phase transition |
| BP | ISS | GO:2000737 | negative regulation of stem cell differentiation |
Gene expression in normal tissue: ZFP36L2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZFP36L2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| wikipathways | WP3527 | Preimplantation Embryo |
| wikipathways | WP3945 | TYROBP Causal Network |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZFP36L2
CLASSFICATION
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