Summary: C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016].

complement C3a receptor 1MIM:605246Ensembl:ENSG00000171860HGNC:HGNC:1319PA2589812p13.31

GO terms in C3AR1

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004875complement receptor activity
MFIBAGO:0004876complement component C3a receptor activity
MFIDAGO:0004876complement component C3a receptor activity
MFIBAGO:0004930G-protein coupled receptor activity
MFIPIGO:0004930G-protein coupled receptor activity
BPIBAGO:0002430complement receptor mediated signaling pathway
BPIDAGO:0002430complement receptor mediated signaling pathway
BPIBAGO:0006954inflammatory response
BPTASGO:0006954inflammatory response
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway
BPIBAGO:0007204positive regulation of cytosolic calcium ion concentration
BPTASGO:0007204positive regulation of cytosolic calcium ion concentration
BPTASGO:0008015blood circulation
BPIEAGO:0010575positive regulation of vascular endothelial growth factor production
BPIEAGO:0010759positive regulation of macrophage chemotaxis
BPTASGO:0030449regulation of complement activation
BPTASGO:0043312neutrophil degranulation
BPIEAGO:0045766positive regulation of angiogenesis
BPIBAGO:0050900leukocyte migration
BPIPIGO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
BPIEAGO:0090023positive regulation of neutrophil chemotaxis
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCTASGO:0035577azurophil granule membrane
CCTASGO:0035579specific granule membrane

Gene expression in normal tissue: C3AR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in C3AR1

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166658Complement cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-977606Regulation of Complement cascade
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04610Complement and coagulation cascades - Homo sapiens (human)
kegghsa05150Staphylococcus aureus infection - Homo sapiens (human)
wikipathwaysWP24Peptide GPCRs
wikipathwaysWP2806Human Complement System
wikipathwaysWP3896Dengue-2 Interactions with Complement and Coagulation Cascades
wikipathwaysWP3941Oxidative Damage
wikipathwaysWP455GPCRs, Class A Rhodopsin-like
wikipathwaysWP558Complement and Coagulation Cascades

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in C3AR1